sodium metabisulfite

disodium disulfite

CAS: 7681-57-4 Na2 O5 S2 MW: 190.10553856

Identification

Namesodium metabisulfite
IUPACdisodium oxidosulfanesulfonate oxide
CAS Number7681-57-4
EINECS231-673-0
FDA UNII4VON5FNS3C
Molecular FormulaNa2 O5 S2
Molecular Weight190.10553856
MDL NumberMFCD00167602
Nikkaji NumberJ44.049C

Regulatory

FDA/DG SANTE Petitions, Reviews, Notices182.3766
JECFA Food AdditiveSodium Metabisulfite
GSFA CodexSodium metabisulfite (223)
DG SANTE Food Additivessodium metabisulphite
FDA Mainterm (SATF)7681-57-4 ; SODIUM METABISULFITE
FDA RegulationFDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance white crystalline powder (est)
Assay 90.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Oral/Parenteral Toxicityoral-rat LD50 1131 mg/kg
Dermal Toxicityskin-rat LD50 > 2000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantibrowning agents, antioxidants, flour treatment agents, preservatives
Recommendation for sodium metabisulfite usage levels up tonot for fragrance use.
Recommendation for sodium metabisulfite flavor usage levels up tonot for flavor use.

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

disodium disulfite disodium metabisulfite disodium oxidosulfanesulfonate oxide disodium pyrosulfite disodium sulfinatosulfonate disulfurous acid sodium salt (1:2) sodium metabisulfite granular sodium metabisulphite sodiummetabisulfite soldium metabisulfite crystals FCC grade sulfanesulfonate, 1-olato-, oxide, sodium salt (1:2) PubMed: The molecular mechanisms of sodium metabisulfite on the expression of KATP and L-Ca(2+) channels in rat hearts. PubMed: Occupational asthma in seafood manufacturing and food allergy to seafood. PubMed: Induction of xanthine oxidase activity, endoplasmic reticulum stress and caspase activation by sodium metabisulfite in rat liver and their attenuation by Ghrelin. PubMed: Effects of sodium metabisulfite on the expression of BK(Ca), K(ATP), and L-Ca(2+) channels in rat aortas in vivo and in vitro. PubMed: Influence of productivity and processing method on physicochemical characteristics of white button mushrooms in Brazil. PubMed: Purification and partial biochemical characterization of polyphenol oxidase from mango (Mangifera indica cv. Manila). PubMed: Development of a selective agar plate for the detection of Campylobacter spp. in fresh produce. PubMed: Post-harvest control of gray mold in table grapes using volatile sulfur compounds from Allium sativum. PubMed: Characterization of a versatile arylesterase from Lactobacillus plantarum active on wine esters. PubMed: Protective role of curcumin against sulfite-induced structural changes in rats' medial prefrontal cortex. PubMed: Curcumin can prevent the changes in cerebellar structure and function induced by sodium metabisulfite in rat. PubMed: Chemical treatments for reducing the yellow discoloration of channel catfish (Ictalurus punctatus) fillets. PubMed: Characterization of three deoxynivalenol sulfonates formed by reaction of deoxynivalenol with sulfur reagents. PubMed: Effects of a Fusarium toxin-contaminated maize treated with sodium metabisulphite, methylamine and calcium hydroxide in diets for female piglets. PubMed: Storage stability of low-fat sodium reduced fresh merguez sausage prepared with olive oil in konjac gel matrix. PubMed: Inactivation of deoxynivalenol-contaminated cereal grains with sodium metabisulfite: a review of procedures and toxicological aspects. PubMed: Curcumin, the main part of turmeric, prevents learning and memory changes induced by sodium metabisulfite, a preservative agent, in rats. PubMed: Hydrothermal treatment of naturally contaminated maize in the presence of sodium metabisulfite, methylamine and calcium hydroxide; effects on the concentration of zearalenone and deoxynivalenol. PubMed: Pigment, physicochemical, and microbiological changes related to the freshness of cracked table olives. PubMed: Ghrelin inhibits sodium metabisulfite induced oxidative stress and apoptosis in rat gastric mucosa. PubMed: Merit of quinacrine in the decrease of ingested sulfite-induced toxic action in rat brain. PubMed: Allergic contact dermatitis caused by sodium metabisulfite: a challenging allergen: a case series and literature review. PubMed: The vasodilator mechanisms of sodium metabisulfite on precontracted isolated aortic rings in rats: signal transduction pathways and ion channels. PubMed: Effect of inert atmosphere on the postharvest browning of manzanilla olives and optimization by response surface methodology of the aqueous treatments. PubMed: Preservation of acidified cucumbers with a combination of fumaric acid and cinnamaldehyde that target lactic acid bacteria and yeasts. PubMed: Effect of processing and packaging conditions on quality of refrigerated potato strips. PubMed: Hippocampal neuron number loss in rats exposed to ingested sulfite. PubMed: Effect of bruising on respiration, superficial color, and phenolic changes in fresh Manzanilla olives (Olea europaea pomiformis): development of treatments to mitigate browning. PubMed: Genotoxicity of sodium metabisulfite in mouse tissues evaluated by the comet assay and the micronucleus test. PubMed: Purification and partial biochemical characterization of polyphenol oxidase from mamey (Pouteria sapota). PubMed: Dose-dependent effect of nutritional sulfite intake on visual evoked potentials and lipid peroxidation. PubMed: Stability of apigeninidin and its methoxylated derivatives in the presence of sulfites. PubMed: Effects of oral exposure of pigs to deoxynivalenol (DON) sulfonate (DONS) as the non-toxic derivative of DON on tissue residues of DON and de-epoxy-DON and on DONS blood levels. PubMed: Investigations on the kinetics of the concentration of deoxynivalenol (DON) and on spoilage by moulds and yeasts of wheat grain preserved with sodium metabisulfite (Na2S2O5, SBS) and propionic acid at various moisture contents. PubMed: Preservation of acidified cucumbers with a natural preservative combination of fumaric acid and allyl isothiocyanate that target lactic acid bacteria and yeasts. PubMed: Sodium metabisulfite induces lipid peroxidation and apoptosis in rat gastric tissue. PubMed: Studies on the toxicity of deoxynivalenol (DON), sodium metabisulfite, DON-sulfonate (DONS) and de-epoxy-DON for porcine peripheral blood mononuclear cells and the Intestinal Porcine Epithelial Cell lines IPEC-1 and IPEC-J2, and on effects of DON and DONS on piglets. PubMed: Modelling the effect of ascorbic acid, sodium metabisulphite and sodium chloride on the kinetic responses of lactic acid bacteria and yeasts in table olive storage using a specifically implemented Quasi-chemical primary model. PubMed: Sodium metabisulfite modulation of potassium channels in pain-sensing dorsal root ganglion neurons. PubMed: Spinal reflexes in normal and sulfite oxidase deficient rats: effect of sulfite exposure. PubMed: Sodium metabisulphite induced airways disease in the fishing and fish-processing industry. PubMed: Effects of a Fusarium toxin-contaminated triticale, either untreated or treated with sodium metabisulphite (Na2S2O5, SBS), on weaned piglets with a special focus on liver function as determined by the 13C-methacetin breath test. PubMed: Effect of sulfite treatment on total antioxidant capacity, total oxidant status, lipid hydroperoxide, and total free sulfydryl groups contents in normal and sulfite oxidase-deficient rat plasma. PubMed: Chlorhexidine with an anti discoloration system after periodontal flap surgery: a cross-over, randomized, triple-blind clinical trial. PubMed: Effect of preservative agents on the respiration rate of minimally processed potato (Solanum tuberosum cv. Monalisa). PubMed: Determination of free and reversibly-bound sulfite in selected foods by high-performance liquid chromatography with fluorometric detection. PubMed: Sodium metabisulfite allergy is common but is it relevant? PubMed: Effect of storage process on the sugars, polyphenols, color and microbiological changes in cracked Manzanilla-Aloreña table olives. PubMed: Media for the aerobic resuscitation of Campylobacter jejuni. PubMed: Pineapple juice and its fractions in enzymatic browning inhibition of banana [Musa (AAA group) Gros Michel]. PubMed: The effect of sulfite and chronic restraint stress on brain lipid peroxidation and anti-oxidant enzyme activities. PubMed: Investigation of Australian olive mill waste for recovery of biophenols. PubMed: Food additive-induced chronic pruritus: further evidence. PubMed: The effects of various antifungal additives on the fermentation and aerobic stability of corn silage. PubMed: The prooxidant effect of sodium metabisulfite in rat liver and kidney. PubMed: The effect of chronic restraint stress and sulfite on visual evoked potentials (VEPs): relation to lipid peroxidation. PubMed: Effect of sulfite on red blood cell deformability ex vivo and in normal and sulfite oxidase-deficient rats in vivo. PubMed: Effect of sulfite on macrophage functions of normal and sulfite oxidase-deficient rats. PubMed: Role of sulfites and 4-hexylresorcinol in microbial growth and melanosis prevention of deepwater pink shrimp (Parapenaeus longirostris) using a controlled atmosphere. PubMed: Effect of preparation conditions on protein secondary structure and biofilm formation of kafirin. PubMed: Effects of sodium metabisulfite on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. PubMed: Gas chromatographic evaluation of pesticide residue contents in nectarines after non-toxic washing treatments. PubMed: Sulfur-containing arsenical mistaken for dimethylarsinous acid [DMA(III)] and identified as a natural metabolite in urine: major implications for studies on arsenic metabolism and toxicity. PubMed: Effect of sodium metabisulphite on germination, growth and yield of Vigna sinensis, Savi. PubMed: Inactivation of Salmonella during drying and storage of apple slices treated with acidic or sodium metabisulfite solutions. PubMed: Urinary metabolites of histamine and leukotrienes before and after placebo-controlled challenge with ASA and food additives in chronic urticaria patients. PubMed: Effect of endogenous triacylglycerol hydrolysates on the mechanical properties of Zein films from ground corn. PubMed: Mycotoxins inactivation by extrusion cooking of corn flour. PubMed: Carotenoid content, physicochemical, and sensory qualities of deep-fried carrot chips as affected by dehydration/rehydration, antioxidant, and fermentation. PubMed: Chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with sodium metabisulfite, a food preservative. PubMed: Absence of adverse effects of sodium metabisulphite in manufactured biscuits: results of subacute (28-days) and subchronic (85-days) feeding studies in rats. PubMed: Contact dermatitis from sodium metabisulfite in a baker. PubMed: An effective lacticin biopreservative in fresh pork sausage. PubMed: Propofol containing sulfite-potential for injury. PubMed: [Effect of cooking on protein digestibility of sorghum (Sorghum bicolor (L.) Moench)]. PubMed: Use and removal of sulfite by conversion to sulfate in the preservation of salt-free cucumbers. PubMed: Effect of sodium metabisulfite on hydrogen peroxide production in light-exposed pediatric parenteral amino acid solutions. PubMed: 4-Hexylresorcinol as inhibitor of shrimp melanosis: efficacy and residues studies; evaluation of possible toxic effect in a human intestinal in vitro model (Caco-2); preliminary safety assessment. PubMed: Utilization of the skin attachment model to determine the antibacterial efficacy of potential carcass treatments. PubMed: [Clinical signs of food allergy]. PubMed: [Chemical and biological evaluation of ripe banana peel]. PubMed: [Prevalence of chronic urticaria following the ingestion of food additives in a third tier hospital]. PubMed: Assessment of food chemical intolerance in adult asthmatic subjects. PubMed: Pickled onion-induced asthma: a model of sulfite-sensitive asthma? PubMed: Microbiological evaluation of dressing procedures for crocodile carcases in Queensland. PubMed: The control of polyphenol oxidase activity in fruits and vegetables. A study of the interactions between the chemical compounds used and heat treatment. PubMed: [Allergy and professional exposure to sulfur compounds: questions posed]. PubMed: [Demonstration of sulfite-group-specific IgE in patients with intolerance to preservatives]. PubMed: Comparison of sulphur dioxide and metabisulphite airway reactivity in subjects with asthma. PubMed: Effect of sulfite intake on intestinal enzyme activity in rats. PubMed: Sodium metabisulfite and SO2 release: an under-recognized hazard among shrimp fishermen. PubMed: Evaluation of phototoxic properties of some food additives: sulfites exhibit prominent phototoxicity. PubMed: Effect of sample pretreatments on the storability of ground melon 'egusi'-Colocynthis citrillus L. PubMed: Disulfite-induced acute intermittent urticaria with vasculitis. PubMed: Toxicology of sulphiting agents. I: Animal studies. PubMed: Precipitation of asthma attacks in Melanesian adults by sodium metabisulphite. PubMed: Mechanisms of metabisulfite-induced bronchoconstriction: evidence for bradykinin B2-receptor stimulation. PubMed: Intolerance to sodium metabisulfite in children with steroid-dependent asthma. PubMed: Effects of heating time and sodium metabisulfite on the nutritional value of full-fat soybeans for chicks. PubMed: Processing and quality evaluation of sweet potato chips. PubMed: Effects of sodium metabisulphite, hydrogen peroxide and heat on aflatoxin B1 in lafun and gari--two cassava products. PubMed: Effect of inhaled preservatives on asthmatic subjects. I. Sodium metabisulfite. PubMed: Viability of Salmonella in bone meal. PubMed: Food and food additives in severe atopic dermatitis. PubMed: [Asthma due to disulfites]. PubMed: Aspirin-like effects of selected food additives and industrial sensitizing agents. PubMed: The structural identification of a secondary dye produced from the reaction between sunset yellow and sodium metabisulphite. PubMed: A double-blind assessment of additive intolerance in children using a 12 day challenge period at home. PubMed: [Frequency of urticaria and angioedema induced by food additives]. PubMed: Oral challenge test with sodium metabisulfite in steroid-dependent asthmatic patients. PubMed: Peroral challenge tests with food additives in urticaria and atopic dermatitis. PubMed: Allergic reaction to sulfiting agents. PubMed: Provocative testing for sulfite sensitivity in clinical allergy. PubMed: [Adverse reactions to food preservatives]. PubMed: Adverse reactions to sulfites. PubMed: Ophthalmic medications that contain sulfites. PubMed: Metabisulfite challenge in patients with idiopathic anaphylaxis. PubMed: Selected enrichment broths for recovery of Campylobacter jejuni from foods. PubMed: Role of acetyl salicylic acid and sodium metabisulfite in chronic childhood asthma. PubMed: Isolation and enumeration of Campylobacter jejuni from poultry products by a selective enrichment method. PubMed: Anaphylaxis to a component of isoetharine (sodium bisulfite). PubMed: Alcohol-induced bronchospasm. PubMed: Bronchospasm induced by metabisulphite-containing foods and drugs. PubMed: Antibotulinal efficacy of sulfur dioxide in meat. PubMed: Viability of Salmonella typhimurium in metabisulphite-treated bone meal: effect of inocula and moisture variation on the lethal potency of metabisulphite. PubMed: A comparative study of the lethal effect of metabisulphite on the viability of three bacterial species in bone meal and gelatin. PubMed: Sodium metabisulfite as a preservative for silage produced from maize plants. PubMed: [Toxicity of sodium metabisulfite for sheep]. PubMed: New quantitative, qualitative, and confirmatory media for rapid analysis of food for Clostridium perfringens. PubMed: Status of iodine in milk preserved with sodium metabisulfite and formaldehyde.