acetophenone, 2'-hydroxy-4'-methoxy- (7CI,8CI)

CAS: 552-41-0 C9 H10 O3 MW: 166.17630000

Identification

Namepeonol
IUPAC1-(2-hydroxy-4-methoxyphenyl)ethanone
CAS Number552-41-0
EINECS209-012-2
FDA UNII3R834EPI82
Molecular FormulaC9 H10 O3
Molecular Weight166.17630000
MDL NumberMFCD00008730
Nikkaji NumberJ4.483K
Beilstein1282794
XlogP32.00 (est)

Regulatory

Physical Properties

Appearance white crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.13100 @ 81.20 °C.
Refractive Index 1.54320 @ 81.20 °C.
Melting Point 50.00 to 53.00 °C. @ 760.00 mm Hg
Boiling Point 301.00 to 302.00 °C. @ 760.00 mm Hg (est), 154.00 °C. @ 20.00 mm Hg
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Flash Point > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w) 1.980
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-mouse LD50 490 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']

Safety in Use

Categoryantioxidants
Recommendation for peonol usage levels up tonot for fragrance use.
Recommendation for peonol flavor usage levels up tonot for flavor use.

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O'Laughlin Industries Inc.

Manufacturer of chemicals and ingredients used in flavors, fragrances, food, beverages and cosmetics

Leading the Flavor and Fragrance Industry since 1980.

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Potential Uses

None Found

Natural Occurrence

campsis grandiflora flower cynanchum stauntonii root daucus gingidium leaf dioscorea japonica root paeonia montana primula auricula

Synonyms

acetophenone, 2'-hydroxy-4'-methoxy- acetophenone, 2'-hydroxy-4'-methoxy- (7CI,8CI) 1- acetyl-2-hydroxy-4-methoxybenzene 2- acetyl-5-methoxy-phenol ethanone, 1-(2-hydroxy-4-methoxyphenyl)- 1-[2- hydroxy-4-(methyloxy)phenyl]ethanone 1-(2- hydroxy-4-methoxy-phenyl)-ethanone 2- hydroxy-4-methoxyacetophenone 1-(2- hydroxy-4-methoxyphenyl) ethanone 1-(2- hydroxy-4-methoxyphenyl)ethanone 2'- hydroxy-4'-methoxyacetophenone 4- methoxy-2-hydroxyacetophenone 4'- methoxy-2'-hydroxyacetophenone 4-O- methyl resacetophenone 4-O- methylresacetophenone paeonol PubMed: Paeonol attenuates advanced oxidation protein product-induced oxidative stress injury in THP-1 macrophages. PubMed: Paeonol suppresses chondrosarcoma metastasis through up-regulation of miR-141 by modulating PKCδ and c-Src signaling pathway. PubMed: Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF-α release. PubMed: Acaricidal potentials of active properties isolated from Cynanchum paniculatum and acaricidal changes by introducing functional radicals. PubMed: Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock. PubMed: Action potential bursts in central snail neurons elicited by paeonol: roles of ionic currents. PubMed: Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. PubMed: Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression. PubMed: Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-kappaB pathway. PubMed: Peroxynitrite mediates high glucose-induced osteoblast apoptosis. PubMed: Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways. PubMed: Acaricidal activities of paeonol and benzoic acid from Paeonia suffruticosa root bark and monoterpenoids against Tyrophagus putrescentiae (Acari: Acaridae). PubMed: Insecticides in Chinese medicinal plants: survey leading to jacaranone, a neurotoxicant and glutathione-reactive quinol. PubMed: Defensive chemistry of the flour beetleTribolium brevicornis (LeC): : Presence of known and potential prostaglandin synthetase inhibitors.