6-paradol

1-(4-hydroxy-3-methoxyphenyl)decan-3-one

CAS: 27113-22-0 C17 H26 O3 MW: 278.39182000 spicy

Identification

Name6-paradol
IUPAC1-(4-hydroxy-3-methoxyphenyl)decan-3-one
CAS Number27113-22-0
EINECS248-228-1
FDA UNIIBO24ID7E9U
Molecular FormulaC17 H26 O3
Molecular Weight278.39182000
Nikkaji NumberJ129.700G
Beilstein1984119
XlogP33.80 (est)

Regulatory

JECFA Food Flavoring2021 1-(4-hydroxy-3-methoxyphenyl)-decan-3-one
DG SANTE Food Flavourings07.234 1-(4-hydroxy-3-methoxyphenyl)-decan-3-one
FEMA Number4665
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)27113-22-0 ; 1-(4-HYDROXY-3-METHOXYPHENYL)DECAN-3-ONE

Physical Properties

Appearance white powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 31.00 to 33.00 °C. @ 760.00 mm Hg
Boiling Point 406.00 to 408.00 °C. @ 760.00 mm Hg
Flash Point 284.00 °F. TCC ( 140.00 °C. )
logP (o/w) 4.225 (est)
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Oral/Parenteral Toxicityintraperitoneal-mouse LD50 270 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic and flavor agents
Recommendation for 6-paradol usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.012 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)420 (μg/person/day)
Threshold of Concern540 (μg/person/day)
Structure ClassII
baked goods-
beverages(nonalcoholic)10.00000
beverages(alcoholic)20.00000
breakfast cereal-
cheese-
chewing gum300.00000
condiments / relishes-
confectionery froastings-
egg products-
fats / oils80.00000
fish products-
frozen dairy50.00000
fruit ices-
gelatins / puddings50.00000
granulated sugar-
gravies-
hard candy50.00000
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products50.00000
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors100.00000
snack foods20.00000
soft candy80.00000
soups20.00000
sugar substitutes-
sweet sauces-
Dairy products, excluding products of category 02.0 (01.0)0.50000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)0.20000
Edible ices, including sherbet and sorbet (03.0)0.50000
Processed fruit (04.1)0.40000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)1.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)0.20000
Bakery wares (07.0)2.00000
Meat and meat products, including poultry and game (08.0)0.20000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)0.20000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)0.30000
Foodstuffs intended for particular nutritional uses (13.0)0.50000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)0.20000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)1.00000
Ready-to-eat savouries (15.0)2.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)0.40000

BOC Sciences

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Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

Symrise AG

Always Insiring More

Symrise aroma molecules & cosmetic ingredients for unique and innovative fragrances, flavors and cosmetics.

View All Website +49 5531 90 0 scentandcare@symrise.com

Vigon International

Passion for Simplicity

Manufacturer and supplier of high quality flavor and fragrance ingredients.

View All Website 570-476-6300 sales@vigon.com

Potential Uses

None Found

Natural Occurrence

ginger rhizome PbMd ginger root oil CO2 extract PbMd ginger root oil CO2 extract australia @ 0.08% Data grains of paradise pepper melegueta pepper PbMd pepper sichuan pepper PbMd PMC

Synonyms

bisabolol, hydroxymethoxyphenyl decanone 3- decanone, 1-(4-hydroxy-3-methoxyphenyl)- 1-(4- hydroxy-3-methoxyphenyl)-3-decanone 1-(4- hydroxy-3-methoxyphenyl)-decan-3-one 1-(4- hydroxy-3-methoxyphenyl)decan-3-one [6]- paradol 5- paradol symdecanox HA (Vigon) symrelief S (Symrise) Google Patents: AROMA COMPOSITION FOR REDUCING OR SUPPRESSING AN UNDESIRED BITTER EU Patents: AROMA COMPOSITION FOR REDUCING OR SUPPRESSING AN UNDESIRED BITTER, ASTRINGENT IMPRESSION PubMed: Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. Google Patents: Formulation with irritation reducing action comprising bisabolol and [6]-paradol PubMed: Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract. PubMed: Relationship between the acyl chain length of paradol analogues and their antiobesity activity following oral ingestion. PubMed: 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling. PubMed: Synthesis of analogues of gingerol and shogaol, the active pungent principles from the rhizomes of Zingiber officinale and evaluation of their anti-platelet aggregation effects. PubMed: [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2. PubMed: Protective effects of [6]-paradol on histological lesions and immunohistochemical gene expression in DMBA induced hamster buccal pouch carcinogenesis. PubMed: Enzyme-assisted extraction of bioactive compounds from ginger (Zingiber officinale Roscoe). PubMed: A new phenanthrene derivative and two diarylheptanoids from the roots of Brassica rapa ssp. campestris inhibit the growth of cancer cell lines and LDL-oxidation. PubMed: Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. PubMed: Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. PubMed: Phenylpropanoid ester from Zingiber officinale and their inhibitory effects on the production of nitric oxide. PubMed: Chemopreventive and antioxidant efficacy of (6)-paradol in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis. PubMed: Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats. PubMed: Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection. PubMed: Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). PubMed: Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. PubMed: Modulation of macrophage functions by compounds isolated from Zingiber officinale. PubMed: In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by [6]-gingerol. PubMed: Cancer preventive properties of ginger: a brief review. PubMed: Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production. PubMed: Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger. PubMed: Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. PubMed: [Studies on the supercritical-CO2 fluid extraction and quality evaluation of ginger oils]. PubMed: Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. PubMed: Antioxidative and antitumor promoting effects of [6]-paradol and its homologs. PubMed: Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. PubMed: Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. PubMed: Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. PubMed: Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol. PubMed: Antimicrobial effectiveness of six paradols. 1: A structure-activity relationship study.