6-shogaol

4- decen-3-one, 1-(4-hydroxy-3-methoxyphenyl)-, (4E)- (E)-1-(4- hydroxy-3-methoxy-phenyl)-dec-4-en-3-one (E)-1-(4- hydroxy-3-methoxy-phenyl)dec-4-en-3-one 1-(4- hydroxy-3-methoxyphenyl)-4-decen-3-one (4E)-1-(4- hydroxy-3-methoxyphenyl)dec-4-en-3-one (E)-1-(4- hydroxy-3-methoxyphenyl)dec-4-en-3-one (6)- shogaol (E)- shogaol [6]- shogaol PubMed: Cytotoxic activity against small cell lung cancer cell line and chromatographic fingerprinting of six isolated compounds from the ethanolic extract of Benjakul. PubMed: Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract. PubMed: Modulation of cytochrome P450 metabolism and transport across intestinal epithelial barrier by ginger biophenolics. PubMed: Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo. PubMed: Anthelmintic constituents from ginger (Zingiber officinale) against Hymenolepis nana. PubMed: [6]-Shogaol inhibits α-MSH-induced melanogenesis through the acceleration of ERK and PI3K/Akt-mediated MITF degradation. PubMed: Influence of side chain structure changes on antioxidant potency of the [6]-gingerol related compounds. PubMed: 6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways. PubMed: 6-shogaol, a major compound in ginger, induces aryl hydrocarbon receptor-mediated transcriptional activity and gene expression. PubMed: 6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia. PubMed: Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells. PubMed: Synthesis and quorum sensing inhibitory activity of key phenolic compounds of ginger and their derivatives. PubMed: Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons. PubMed: 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling. PubMed: Variations in the contents of gingerols and chromatographic fingerprints of ginger root extracts prepared by different preparation methods. PubMed: Role of 6-shogaol in tert -butyl hydroperoxide-induced apoptosis of HepG2 cells. PubMed: Reply to Comments on the article "[6]-Shogaol induced calcium signal in rat insulinoma cells". PubMed: Comments on the article "[6]-Shogaol induced calcium signal in rat insulinoma cells". PubMed: Multitargeted effects of hangeshashinto for treatment of chemotherapy-induced oral mucositis on inducible prostaglandin E2 production in human oral keratinocytes. PubMed: Induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite M2. PubMed: Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract. PubMed: Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-κB signaling by 6-shogaol. PubMed: [6]-shogaol induces Ca²⁺ signals by activating the TRPV1 channels in the rat insulinoma INS-1E cells. PubMed: Inhibition of human low-density lipoprotein oxidation in vitro by ginger extracts. PubMed: Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells. PubMed: [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2. PubMed: 6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α. PubMed: 6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity. PubMed: Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. PubMed: A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways. PubMed: 6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation. PubMed: Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice. PubMed: 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). PubMed: [6]-Shogaol inhibits the production of proinflammatory cytokines via regulation of NF-κB and phosphorylation of JNK in HMC-1 cells. PubMed: Glutathione conjugation attenuates biological activities of 6-dehydroshogaol from ginger. PubMed: Population pharmacokinetic analysis of daikenchuto, a traditional Japanese medicine (Kampo) in Japanese and US health volunteers. PubMed: 6-Shogaol Protects against Oxidized LDL-Induced Endothelial Injruries by Inhibiting Oxidized LDL-Evoked LOX-1 Signaling. PubMed: Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. PubMed: Highly efficient sample preparation and quantification of constituents from traditional Chinese herbal medicines using matrix solid-phase dispersion extraction and UPLC-MS/MS. PubMed: Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. PubMed: A new phenanthrene derivative and two diarylheptanoids from the roots of Brassica rapa ssp. campestris inhibit the growth of cancer cell lines and LDL-oxidation. PubMed: Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasion. PubMed: [6]-shogaol attenuates neuronal apoptosis in hydrogen peroxide-treated astrocytes through the up-regulation of neurotrophic factors. PubMed: Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation. PubMed: Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. PubMed: Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol. PubMed: Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. PubMed: Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine. PubMed: The Cytotoxicity Mechanism of 6-Shogaol-Treated HeLa Human Cervical Cancer Cells Revealed by Label-Free Shotgun Proteomics and Bioinformatics Analysis. PubMed: Simultaneous determination of gingerols and shogaol using capillary liquid chromatography and its application in discrimination of three ginger varieties from Indonesia. PubMed: [Effect of Zingiber offiicinale and Aconitum cainichaeli before and after compatibility on contents of four gingerols]. PubMed: [6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway. PubMed: Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation. PubMed: Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry. PubMed: In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. PubMed: Anti-platelet aggregation and vasorelaxing effects of the constituents of the rhizomes of Zingiber officinale. PubMed: 6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress. PubMed: 6-shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice. PubMed: Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol. PubMed: Optimization of Extraction Conditions for the 6-Shogaol-rich Extract from Ginger (Zingiber officinale Roscoe). PubMed: Zingiber officinale (ginger) as an anti-emetic in cancer chemotherapy: a review. PubMed: Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae. PubMed: 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. PubMed: Effects of [6]-shogaol on cholinergic signaling in HT22 cells following neuronal damage induced by hydrogen peroxide. PubMed: Phenylpropanoid ester from Zingiber officinale and their inhibitory effects on the production of nitric oxide. PubMed: [Phenolic and amide constituents from Lycianthes marlipoensis]. PubMed: Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger. PubMed: Metabolism of [6]-shogaol in mice and in cancer cells. PubMed: Protection by [6]-shogaol against lipopolysaccharide-induced toxicity in murine astrocytes is related to production of brain-derived neurotrophic factor. PubMed: Anti-inflammatory effects of [6]-shogaol: potential roles of HDAC inhibition and HSP70 induction. PubMed: Pharmacokinetics of daikenchuto, a traditional Japanese medicine (kampo) after single oral administration to healthy Japanese volunteers. PubMed: Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells. PubMed: Examination of the pharmacokinetics of active ingredients of ginger in humans. PubMed: Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation. PubMed: Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivatives. PubMed: Ginger suppresses phthalate ester-induced airway remodeling. PubMed: Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats. PubMed: Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. PubMed: Preparation of the monomers of gingerols and 6-shogaol by flash high speed counter-current chromatography. PubMed: Quantitation of 6-, 8- and 10-Gingerols and 6-Shogaol in Human Plasma by High-Performance Liquid Chromatography with Electrochemical Detection. PubMed: 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. PubMed: Profiling of the compounds absorbed in human plasma and urine after oral administration of a traditional Japanese (kampo) medicine, daikenchuto. PubMed: Effect of [6]-shogaol on cytosolic Ca2+ levels and proliferation in human oral cancer cells (OC2). PubMed: Zingiber officinale (ginger) compounds have tetracycline-resistance modifying effects against clinical extensively drug-resistant Acinetobacter baumannii. PubMed: Larvicidal constituents of Zingiber officinale (ginger) against Anisakis simplex. PubMed: Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells. PubMed: [Chemical constituents of rhizomes of Zingiber officinale]. PubMed: 6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. PubMed: Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I). PubMed: Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents. PubMed: Six-shogaol inhibits production of tumour necrosis factor alpha, interleukin-1 beta and nitric oxide from lipopolysaccharide-stimulated RAW 264.7 macrophages. PubMed: Larvicidal activities of ginger (Zingiber officinale) against Angiostrongylus cantonensis. PubMed: Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. PubMed: Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. PubMed: 6-Shogaol inhibits monosodium urate crystal-induced inflammation--an in vivo and in vitro study. PubMed: Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry. PubMed: 6-Shogaol, an active constituent of dietary ginger, induces autophagy by inhibiting the AKT/mTOR pathway in human non-small cell lung cancer A549 cells. PubMed: Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. PubMed: TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, an active component of ginger. PubMed: Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol. PubMed: [Analysis of volatile and non-volatile compositions in ginger oleoresin by gas chromatography-mass spectrometry]. PubMed: Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics. PubMed: Modulation of macrophage functions by compounds isolated from Zingiber officinale. PubMed: Specific reaction of alpha,beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage. PubMed: Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood. PubMed: Analysis of anti-platelet aggregation components of Rhizoma Zingiberis using chicken thrombocyte extract and high performance liquid chromatography. PubMed: Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. PubMed: 6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. PubMed: [RP-HPLC fingerprint evaluating different ginger juice as processing material]. PubMed: 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. PubMed: Changes in the contents of oleoresin and pungent bioactive principles of Jamaican ginger (Zingiber officinale Roscoe.) during maturation. PubMed: Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe. PubMed: 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. PubMed: Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells. PubMed: Liquid chromatographic determination of 6-, 8-, 10-gingerol, and 6-shogaol in ginger (Zingiber officinale) as the raw herb and dried aqueous extract. PubMed: Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids. PubMed: Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. PubMed: High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages. PubMed: 6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism. PubMed: A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1. PubMed: 6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant. PubMed: 6-Shogaol, a natural product, reduces cell death and restores motor function in rat spinal cord injury. PubMed: Species differences in the prokinetic effects of ginger. PubMed: Variation in concentration and labeling of ginger root dietary supplements. PubMed: The effect of extracts from ginger rhizome on inflammatory mediator production. PubMed: Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. PubMed: Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. PubMed: 5-HT3 receptor blocking activity of arylalkanes isolated from the rhizome of Zingiber officinale. PubMed: Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production. PubMed: Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine. PubMed: Component of Zingiber officinale that improves the enhancement of small intestinal transport. PubMed: The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats. PubMed: The stability of gingerol and shogaol in aqueous solutions. PubMed: Stomachic principles in ginger. III. An anti-ulcer principle, 6-gingesulfonic acid, and three monoacyldigalactosylglycerols, gingerglycolipids A, B, and C, from Zingiberis Rhizoma originating in Taiwan. PubMed: Capsaicin-like effect of (6)-shogaol on substance P-containing primary afferents of rats: a possible mechanism of its analgesic action. PubMed: [Stomachic principles in ginger. II. Pungent and anti-ulcer effects of low polar constituents isolated from ginger, the dried rhizoma of Zingiber officinale Roscoe cultivated in Taiwan. The absolute stereostructure of a new diarylheptanoid]. PubMed: 6-Gingesulfonic acid, a new anti-ulcer principle, and gingerglycolipids A, B, and C, three new monoacyldigalactosylglycerols, from zingiberis rhizoma originating in Taiwan. PubMed: [The study of Chinese herbal medicinal prescription with enzyme inhibitory activity. V. The study of hange-shashin-to, kanzo-shashin-to, shokyo-shashin-to with adenosine 3',5'-cyclic monophosphate phosphodiesterase]. PubMed: [The effect of ginger on serotonin induced hypothermia and diarrhea]. PubMed: Gastrointestinal motility enhancing effect of ginger and its active constituents. PubMed: Lethal efficacy of extract from Zingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro. PubMed: Reversed effects between crude and processed ginger extracts on PGF2 alpha-induced contraction in mouse mesenteric veins. PubMed: Chemical structural requirement in gingerol derivatives for potentiation of prostaglandin F2 alpha-induced contraction in isolated mesenteric veins of mice. PubMed: [Pharmacological studies on ginger. V. Pharmacological comparison between (6)-shogaol and capsaicin]. PubMed: Pharmacological studies on ginger. II. Pressor action of (6)-shogaol in anesthetized rats, or hindquarters, tail and mesenteric vascular beds of rats. PubMed: [Pharmacological studies on ginger. IV. Effect of (6)-shogaol on the arachidonic cascade]. PubMed: Pharmacological studies on ginger. III. Effect of the spinal destruction on (6)-shogaol-induced pressor response in rats. PubMed: Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol. PubMed: The active part of the [6]-gingerol molecule in mutagenesis.