Potential Uses
FR
amber
FL
fruit tropical fruit
FR
moss
FR
pina colada
FR
tonka bean
FL
tropical
FR
tuberose
Natural Occurrence
muskmelon
Synonyms
benzenemethanol, 4-hydroxy-
benzyl alcohol, 4-hydroxy-
benzyl alcohol, p-hydroxy-
4-
hydroxy benzyl alcohol
p-
hydroxy benzyl alcohol
4-
hydroxy-benzyl-alcohol
alpha-
hydroxy-p-cresol
alpha-
hydroxy-para-cresol
4-
hydroxybenzenemethanol
p-
hydroxybenzyl alcohol
para-
hydroxybenzyl alcohol
4-
hydroxybenzylalcohol
hydroxymethyl) phenol
4-(
hydroxymethyl) phenol
4-(
hydroxymethyl)phenol
p-(
hydroxymethyl)phenol
(4-
hydroxyphenyl)methanol
4-
methylol phenol
p-
methylol phenol
para-
methylol phenol
4-
methylolphenol
p-
methylolphenol
para-
methylolphenol
PubMed:
Analysis and pharmacokinetics studies of gastrodin and p-hydroxybenzyl alcohol in dogs using ultra fast liquid chromatography-tandem mass spectrometry method.
PubMed:
Identification and analysis of gastrodin and its five metabolites using ultra fast liquid chromatography electrospray ionization tandem mass spectrometry to investigate influence of multiple-dose and food.
PubMed:
Lipase catalyzed inclusion of gastrodigenin for the evolution of blue light emitting peptide nanofibers.
PubMed:
[Study on the chemical constituents of Gastrodia elata].
PubMed:
Rational design, synthesis and biological evaluation of modular fluorogenic substrates with high affinity and selectivity for PTP1B.
PubMed:
Genetic characterization of 4-cresol catabolism in Corynebacterium glutamicum.
PubMed:
[Study on effect of combined application on distribution of gastrodigenin in rats].
PubMed:
Expression profiles of key phenylpropanoid genes during Vanilla planifolia pod development reveal a positive correlation between PAL gene expression and vanillin biosynthesis.
PubMed:
Hydrogen peroxide-responsive copolyoxalate nanoparticles for detection and therapy of ischemia-reperfusion injury.
PubMed:
Hydrolysis of the quinone methide of butylated hydroxytoluene in aqueous solutions.
PubMed:
4-hydroxybenzyl alcohol: a novel inhibitor of tumor angiogenesis and growth.
PubMed:
4-Hydroxybenzyl alcohol confers neuroprotection through up-regulation of antioxidant protein expression.
PubMed:
Application parameters of laccase-mediator systems for treatment of sulfonamide antibiotics.
PubMed:
New anthraquinone derivatives from Geosmithia lavendula.
PubMed:
An improved fluorogenic substrate for the detection of alkaline phosphatase activity.
PubMed:
Gastrodin production from p-2-hydroxybenzyl alcohol through biotransformation by cultured cells of Aspergillus foetidus and Penicillium cyclopium.
PubMed:
Experimental analysis on the main contents of Rhizoma gastrodiae extract and inter-transformation throughout the fermentation process of Grifola frondosa.
PubMed:
Exploration of Vanilla pompona from the Peruvian Amazon as a potential source of vanilla essence: quantification of phenolics by HPLC-DAD.
PubMed:
[Chemical constituents from Hypericum perforatum].
PubMed:
[Intestinal absorption characteristics of gastrodigenin in rats].
PubMed:
The implication of mediators for enhancement of laccase oxidation of sulfonamide antibiotics.
PubMed:
Gastrodia elata Blume and its pure compounds protect BV-2 microglial-derived cell lines against β-amyloid: the involvement of GRP78 and CHOP.
PubMed:
Modulation of LPS-stimulated neuroinflammation in BV-2 microglia by Gastrodia elata: 4-hydroxybenzyl alcohol is the bioactive candidate.
PubMed:
[One new lignan glycoside from whole plants of Senecio chrysanthemoides].
PubMed:
In vitro and in vivo evaluation of the anti-angiogenic actions of 4-hydroxybenzyl alcohol.
PubMed:
p-Hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia.
PubMed:
[Constituents of Gymnadenia conopsea].
PubMed:
Reduction of oxidative stress by p-hydroxybenzyl alcohol-containing biodegradable polyoxalate nanoparticulate antioxidant.
PubMed:
Predicting the substrate specificity of a glycosyltransferase implicated in the production of phenolic volatiles in tomato fruit.
PubMed:
4-hydroxybenzyl alcohol ameliorates cerebral injury in rats by antioxidant action.
PubMed:
Linking NE1545 gene expression with cell volume changes in Nitrosomonas europaea cells exposed to aromatic hydrocarbons.
PubMed:
Antioxidant and anti-inflammatory activities of hydroxybenzyl alcohol releasing biodegradable polyoxalate nanoparticles.
PubMed:
Supercritical fluid chromatography of myrosinase reaction products in ground yellow mustard seed oil.
PubMed:
Secondary metabolites of the phytopathogen Peronophythora litchii.
PubMed:
[Simultaneous determination of four components in Gastrodia elata by RP-HPLC].
PubMed:
Metabolites from endophytic fungus S20 of Cephalotaxus hainanensis.
PubMed:
A cascade biodegradable polymer based on alternating cyclization and elimination reactions.
PubMed:
Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats.
PubMed:
Biosynthesis of vanillin via ferulic acid in Vanilla planifolia.
PubMed:
Experimental stroke protection induced by 4-hydroxybenzyl alcohol is cancelled by bacitracin.
PubMed:
Microfluidic synthesis and catalytic application of PVP-stabilized, approximately 1 nm gold clusters.
PubMed:
Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS.
PubMed:
Purification and characterization of active-site components of the putative p-cresol methylhydroxylase membrane complex from Geobacter metallireducens.
PubMed:
Phenolic glucosides from the leaves of Pieris japonica.
PubMed:
[Brain targeting of gastrodin nasal in situ gel].
PubMed:
Determination and pharmacokinetics of gastrodin and p-hydroxybenzylalcohol after oral administration of Gastrodia elata Bl. extract in rats by high-performance liquid chromatography-electrospray ionization mass spectrometric method.
PubMed:
Biotransformation and pharmacokinetics of 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-beta-D-glucopyranoside, an antioxidant isolated from Origanum vulgare.
PubMed:
The photo-Favorskii reaction of p-hydroxyphenacyl compounds is initiated by water-assisted, adiabatic extrusion of a triplet biradical.
PubMed:
Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration.
PubMed:
Distribution and metabolism of gastrodin in rat brain.
PubMed:
Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia.
PubMed:
Anti-angiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol.
PubMed:
Studies on the antioxidant activities of natural vanilla extract and its constituent compounds through in vitro models.
PubMed:
[Evaluation of the quality of Gastrodia elata Bl. by HPLC-DAD/MS].
PubMed:
Inhibitory effect of p-hydroxybenzyl alcohol on tyrosinase activity and melanogenesis.
PubMed:
Genes, enzymes, and regulation of para-cresol metabolism in Geobacter metallireducens.
PubMed:
Phenolic constituents from the rhizomes of Gastrodia elata.
PubMed:
Development and validation of an RP-HPLC method for quantitative determination of vanillin and related phenolic compounds in Vanilla planifolia.
PubMed:
[The production of gastrodin through biotransformation of p-hydroxybenzaldehyde by cell suspension culture of Datura stramonium].
PubMed:
A new citryl glycoside from Gastrodia elata and its inhibitory activity on GABA transaminase.
PubMed:
Anti-inflammatory action of phenolic compounds from Gastrodia elata root.
PubMed:
[Production of gastrodin through biotransformation of p-hydroxybenzaldehyde by cell suspension cultures of Datura tatula L].
PubMed:
Chemical fingerprint analysis of rhizomes of Gymnadenia conopsea by HPLC-DAD-MSn.
PubMed:
Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice.
PubMed:
Colorimetric evaluation of phenolic content and GC-MS characterization of phenolic composition of alimentary and cosmetic argan oil and press cake.
PubMed:
Gastrodia elata blume and an active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions.
PubMed:
[Chemical constituents from the rhizoma of Arundina graminifolia].
PubMed:
New phenolic glycosides from the seeds of Cucurbita moschata.
PubMed:
Metabolism of gallic acid and catechin by Lactobacillus hilgardii from wine.
PubMed:
Chemical constituents of the rhizomes of Coeloglossum viride var. bracteatum.
PubMed:
4-Hydroxybenzyl alcohol accumulates in flowers and developing fruits of carrot and inhibits seed formation.
PubMed:
Substituent effects on carbocation stability: the pK(R) for p-quinone methide.
PubMed:
Vanillin.
PubMed:
Metabolism of benzyl alcohol via catechol ortho-pathway in methylnaphthalene-degrading Pseudomonas putida CSV86.
PubMed:
Polymer-supported reagents for methylphosphorylation and phosphorylation of carbohydrates.
PubMed:
Flash photolytic generation and study of p-quinone methide in aqueous solution. An estimate of rate and equilibrium constants for heterolysis of the carbon-bromine bond in p-hydroxybenzyl bromide.
PubMed:
4-Hydroxycinnamoyl-CoA hydratase/lyase, an enzyme of phenylpropanoid cleavage from Pseudomonas, causes formation of C(6)-C(1) acid and alcohol glucose conjugates when expressed in hairy roots of Datura stramonium L.
PubMed:
Evidence of a new biotransformation pathway of p-coumaric acid into p-hydroxybenzaldehyde in Pycnoporus cinnabarinus.
PubMed:
In vitro effects of hydroxybenzaldehydes from Gastrodia elata and their analogues on GABAergic neurotransmission, and a structure-activity correlation.
PubMed:
A germacranolide and three hydroxybenzyl alcohol derivatives from Hieracium murorum and Crepis bocconi.
PubMed:
Determination of the active ingredients in Gastrodia rhizoma by capillary electrophoresis with electrochemical detection.
PubMed:
Studies on the reaction of p-hydroxybenzyl alcohol and hydroxyl radicals.
PubMed:
Identification of novel polyphenol oxidase inhibitors by enzymatic one-pot synthesis and deconvolution of combinatorial libraries.
PubMed:
4-Hydroxybenzyl alcohol accumulates in suspension-cell cultures and inhibits somatic embryogenesis in carrot.
PubMed:
Properties of diphenolase from Vanilla planifolia (Andr.) shoot primordia cultured in vitro.
PubMed:
Rerouting the plant phenylpropanoid pathway by expression of a novel bacterial enoyl-CoA hydratase/lyase enzyme function.
PubMed:
Simultaneous determination of p-hydroxybenzaldehyde, p-hydroxybenzyl alcohol, 4-(beta-D-glucopyranosyloxy)-benzyl alcohol, and sugars in Gastrodia elata blume measured as their acetylated derivatives by GC-MS.
PubMed:
Effects of noncovalent and covalent FAD binding on the redox and catalytic properties of p-cresol methylhydroxylase.
PubMed:
Free and bound volatile composition and characterization of some glucoconjugates as aroma precursors in melón de olor fruit pulp (Sicana odorifera).
PubMed:
4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain.
PubMed:
Supercritical fluid chromatography as a method of analysis for the determination of 4-hydroxybenzylglucosinolate degradation products.
PubMed:
Action mechanism of tyrosinase on meta- and para-hydroxylated monophenols.
PubMed:
Purification from conditioned medium and chemical identification of a factor that inhibits somatic embryogenesis in carrot.
PubMed:
Natural mediators in the oxidation of polycyclic aromatic hydrocarbons by laccase mediator systems.
PubMed:
Structures of the flavocytochrome p-cresol methylhydroxylase and its enzyme-substrate complex: gated substrate entry and proton relays support the proposed catalytic mechanism.
PubMed:
Properties of p-cresol methylhydroxylase flavoprotein overproduced by Escherichia coli.
PubMed:
Synthesis and folding of native collagen III model peptides.
PubMed:
Cresol metabolism by the sulfate-reducing bacterium Desulfotomaculum sp. strain Groll.
PubMed:
areABC genes determine the catabolism of aryl esters in Acinetobacter sp. Strain ADP1.
PubMed:
Isolation of 3-O-(4'-hydroxybenzyl)-beta-sitosterol and 4-[4'-(4"-hydroxybenzyloxy)benzyloxy]benzyl methyl ether from fresh tubers of Gastrodia elata.
PubMed:
Biotransformation of the major fungal metabolite 3,5-dichloro- p-anisyl alcohol under anaerobic conditions and its role in formation of Bis(3,5-dichloro-4-Hydroxyphenyl)methane.
PubMed:
Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: interactions with compounds acting at 5-HT1A and 5-HT2 receptors.
PubMed:
Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in rats.
PubMed:
Melanogenesis-targeted anti-melanoma pro-drug development: effect of side-chain variations on the cytotoxicity of tyrosinase-generated ortho-quinones in a model screening system.
PubMed:
Effects of Gastrodia elata and its active constituents on scopolamine-induced amnesia in rats.
PubMed:
Potent inhibition of spontaneous rhythmic contraction by a novel beta 2-adrenoceptor agonist, HSR-81, in pregnant rat uterus.
PubMed:
p-Hydroxybenzyl alcohol attenuates learning deficits in the inhibitory avoidance task: involvement of serotonergic and dopaminergic systems.
PubMed:
[Biodistribution and metabolism of 3H-gastrodigenin and 3H-gastrodin in mice].
PubMed:
Regulation of chloro- and methylphenol degradation in Comamonas testosteroni JH5.
PubMed:
[125I-alpha-sec-butyl-p-hydroxybenzyl alcohol receptor competitive binding assays in animal body].
PubMed:
Cresol isomers: comparison of toxic potency in rat liver slices.
PubMed:
[Identification of the metabolites of T-018 in the urine in female rats].
PubMed:
New Phenolic Derivatives from Galeola faberi.
PubMed:
Antioxidant and pro-oxidant activities of p-hydroxybenzyl alcohol and vanillin: effects on free radicals, brain peroxidation and degradation of benzoate, deoxyribose, amino acids and DNA.
PubMed:
Metabolism of p-Cresol by the Fungus Aspergillus fumigatus.
PubMed:
[Studies on the phenolic derivatives from Galeola faberi Rolfe].
PubMed:
Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum. A novel aromatic alcohol oxidase containing covalently bound FAD.
PubMed:
The acute toxicity of pulse-dosed, para-substituted phenols to larval American flagfish (Jordanella floridae): a comparison with toxicity to photoluminescent bacteria and predicted toxicity using log Kow.
PubMed:
[Study of the mechanism of gastrodin and derivatives of gastrodigenin].
PubMed:
p-cresol methylhydroxylase from a denitrifying bacterium involved in anaerobic degradation of p-cresol.
PubMed:
[A trial of utilizing TDP (specific electromagnetic wave) in cultivating Gastrodia elata Bl].
PubMed:
Biotransformations of aromatic aldehydes by acetogenic bacteria.
PubMed:
Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium.
PubMed:
[The distribution of 3H-alpha-sec-butyl-p hydroxybenzyl alcohol in mice].
PubMed:
Formation of oedema and accumulation of eosinophils in the guinea pig lung. Inhibition by inhaled beta-stimulants.
PubMed:
[Determination of gastrodin in biological specimens and in pharmacokinetics].
PubMed:
Simultaneous determination of gastrodin and its metabolite by HPLC.
PubMed:
Anaerobic oxidation of p-cresol by a denitrifying bacterium.
PubMed:
Isolation and characterization of multiple forms of mandelonitrile lyase from mature black cherry (Prunus serotina Ehrh.) seeds.
PubMed:
Sensitizing capacity of 2-methylol phenol, 4-methylol phenol and 2,4,6-trimethylol phenol in the guinea pig.
PubMed:
p-Cresol methylhydroxylase. Assay and general properties.
PubMed:
Mutagenicity studies of p-substituted benzyl derivatives in the Ames Salmonella plate-incorporation assay.
PubMed:
Metabolism of a new cardiotonic agent, (-)-alpha-(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol (TA-064), in man. O-demethylation and ring hydroxylation.
PubMed:
Evaluation of models for the mechanism of action of 4-hydroxyphenylpyruvate dioxygenase.
PubMed:
The choleretic mechanism of coumarin compounds and phenolic compounds.
PubMed:
New bromoperoxidases of marine origin: partial purification and characterization.
PubMed:
4-Hydroxybenzyl alcohol. A metabolite produced during the biosynthesis of thiamine in Escherichia coli.
PubMed:
The aromatic alcohol dehydrogenases in Pseudomonas putida N.C.I.B. 9869 grown on 3,5-xylenol and p-cresol.
PubMed:
P-cresol and 3,5-xylenol methylhydroxylases in Pseudomonas putida N.C.I.B. 9896.
PubMed:
Incorporation of [18O]water in the formation of p-hydroxybenzyl alcohol by the p-cresol methylhydroxylase from Pseudomonas putida.
PubMed:
The purification and properties of p-cresol-(acceptor) oxidoreductase (hydroxylating), a flavocytochrome from Pseudomonas putida.
PubMed:
Diazotization of catecholamines and their analogs and metabolites for urinary screening tests: chemical aspects.
PubMed:
Ageing of Neurospora crassa. III. Induction of cellular death and clonal senescence of an inositol-less mutant by inositol starvation and the protective effect of dietary antioxidants.
PubMed:
The Sulphation of p-hydroxyphenylpyruvic acid and related compounds by the rat liver cytosol.
PubMed:
Simple brominated phenols in the bluegreen alga Calothrix brevissima West.
PubMed:
[Formation of an ascorbigen-like product from p-hydroxybenzyl alcohol and L-ascorbic acid].
PubMed:
Bromophenols from red algae.