dextro,laevo-leucine

DL-2-amino-4-methylpentanoic acid

CAS: 328-39-2 C6 H13 N O2 MW: 131.17501000

Identification

Namedextro,laevo-leucine
IUPAC2-amino-4-methylpentanoic acid
CAS Number328-39-2
EINECS206-328-2
FDA UNII1QSS9D5DR6
Molecular FormulaC6 H13 N O2
Molecular Weight131.17501000
MDL NumberMFCD00063087
Nikkaji NumberJ1.285H
Beilstein636005

Regulatory

Physical Properties

Appearance white crystals (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 293.00 to 296.00 °C. @ 760.00 mm Hg
Boiling Point 225.77 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.031000 mmHg @ 25.00 °C. (est)
Flash Point 195.00 °F. TCC ( 90.30 °C. ) (est)
logP (o/w) 0.799 (est)
Soluble in water, 1.18E+04 mg/L @ 25 °C (exp)

Organoleptic Properties

Odor Description odorless

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for dextro,laevo-leucine usage levels up tonot for fragrance use.
Recommendation for dextro,laevo-leucine flavor usage levels up tonot for flavor use.

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Potential Uses

antistatic agents

Natural Occurrence

not found in nature

Synonyms

2- amino-4-methylpentanoic acid DL-2- amino-4-methylpentanoic acid 2- amino-4-methylvaleric acid DL-2- amino-4-methylvaleric acid a- aminoisocaproic acid (±)- leucine (RS)- leucine leucine, DL- pentanoic acid, 2-amino-4-methyl- valeric acid, 2-amino-4-methyl- PubMed: Isolation and characterization of awamori yeast mutants with l-leucine accumulation that overproduce isoamyl alcohol. PubMed: Thiol-ene click chemistry derived cationic cyclodextrin chiral stationary phase and its enhanced separation performance in liquid chromatography. PubMed: The treatment and natural course of peripheral and central vertigo. PubMed: Intermolecular vibrations in hydrophobic amino acid crystals: experiments and calculations. PubMed: Effects of acetyl-DL-leucine in patients with cerebellar ataxia: a case series. PubMed: One-step synthesis of silver/dopamine nanoparticles and visual detection of melamine in raw milk. PubMed: Non-ionic surfactant modified ligand exchange chromatography using copper (II) complex of N,N-dimethyl-L-phenylalanine as the chiral additive for enantioselective amino acids separation. PubMed: Dual role of hydrophobic racemic thioesters of alpha-amino acids in the generation of isotactic peptides and co-peptides in water; implications for the origin of homochirality. PubMed: Highly sensitive detection of chiral amino acids by CE based on on-line stacking techniques. PubMed: Mixed ligand complexes of benzimidazole and pyrimidine hydroxy azo dyes with some transition metals and glycine, dl-alanine or dl-leucine. PubMed: Effects of acetyl-DL-leucine in vestibular patients: a clinical study following neurotomy and labyrinthectomy. PubMed: Oligopeptides and copeptides of homochiral sequence, via beta-sheets, from mixtures of racemic alpha-amino acids, in a one-pot reaction in water; relevance to biochirogenesis. PubMed: Direct lung delivery of a dry powder formulation of DTPA with improved aerosolization properties: effect on lung and systemic decorporation of plutonium. PubMed: Partial molar volumes of some alpha-amino acids in aqueous sodium acetate solutions at 308.15 K. PubMed: Isolation of Saccharomyces cerevisiae strains producing higher levels of flavoring compounds for production of "cachaça" the Brazilian sugarcane spirit. PubMed: Asp578 in LEU4p is one of the key residues for leucine feedback inhibition release in sake yeast. PubMed: Construction of two new vectors for transformation of laboratory, natural and industrial Saccharomyces cerevisiae strains to trifluoroleucine and G418 resistance. PubMed: Evaluation of in vitro antimicrobial and in vivo cytotoxic properties of some novel titanium-based coordination complexes. PubMed: Viscosity behavior of some alpha-amino acids and their groups in water-sodium acetate mixtures. PubMed: Autoradiography in brain of Macaca fascicularis monkeys after injection of acetyl-DL-leucine [2-14C] (Tanganil). PubMed: Supported liquid membrane stability in chiral resolution by chemically and physically modified membranes. PubMed: Cryo-bioorganic chemistry: freezing effect on stereoselection of L- and DL-leucine cooligomerization in aqueous solution. PubMed: In vitro effects of acetyl-DL-leucine (tanganil) on central vestibular neurons and vestibulo-ocular networks of the guinea-pig. PubMed: Racemic dipeptide glycyl-DL-leucine at 120 K. PubMed: Effect of temperature on viscosity properties of some alpha-amino acids in aqueous urea solutions. PubMed: Direct thin layer chromatography enantioresolution of some basic DL-amino acids using a pharmaceutical industry waste as chiral impregnating reagent. PubMed: Trifluoroleucine resistance as a dominant molecular marker in transformation of strains of Saccharomyces cerevisiae isolated from wine. PubMed: Trifluoroleucine resistance and regulation of alpha-isopropyl malate synthase in Saccharomyces cerevisiae. PubMed: [Effects of acetyl-DL-leucine on the recovery of the locomotor equilibrium and spontaneous discharge of lateral vestibular nucleus neurons in unilateral vestibular neurectomized cats]. PubMed: DL-leucine transport in a Saccharomyces cerevisiae mutant resistant to quaternary ammonium salts. PubMed: Enhanced formation of isoamyl alcohol in Zygosaccharomyces rouxii due to elimination of feedback inhibition of alpha-isopropylmalate synthase. PubMed: [Drug therapy of vertigo]. PubMed: On the 13C CP/MAS spectra of leucine. PubMed: Production and immobilization of D-aminoacylase of Alcaligenes faecalis DA1 for optical resolution of N-acyl-DL-amino acids. PubMed: Retinamides: hydrolytic conversion of retinoylglycine to retinoic acid in pregnant mice contributes to teratogenicity. PubMed: Genetic analysis of the Pseudomonas aeruginosa PAO high-affinity branched-chain amino acid transport system by use of plasmids carrying the bra genes. PubMed: Thiol-based inhibitors of mammalian collagenase. Substituted amide and peptide derivatives of the leucine analogue, 2-[(R,S)-mercaptomethyl]-4-methylpentanoic acid. PubMed: Inhibition of Moloney murine lymphoma and sarcoma growth in vivo by dietary retinoids. PubMed: Production of d-Aminoacylase from Alcaligenes denitrificans subsp. xylosoxydans MI-4. PubMed: Toxicologic and immunologic evaluations of N-(all-trans-retinoyl)-DL-leucine and N-(all-trans-retinoyl)glycine. PubMed: Production and Purification of d-Aminoacylase from Alcaligenes denitrificans and Taxonomic Study of the Strain. PubMed: Soft agar colony formation of bladder cells during carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine and application to detection of bladder cancer promoters. PubMed: Characterization of novel viral polyproteins detected in cells infected by the flavivirus Kunjin and radiolabelled in the presence of the leucine analogue hydroxyleucine. PubMed: Models of molecular evolution. 2. Stereospecificity of dipeptide syntheses by means of cyanamides and carbodiimides. PubMed: A comparison of cationic polymerization and esterification for end-point detection in the catalytic thermometric titration of organic bases. PubMed: [Comparative distribution study of 14C labeled amino acids, glucose-analogue and precursor of nuclei acid, as tumor seeking agents]. PubMed: On the stereoselective aminoacylation of RNA. PubMed: Beta-decay, bremsstrahlen, and the origin of molecular chirality. PubMed: Metabolism of leucine by the isolated perfused goat udder. PubMed: Evidence that repression mechanisms can exert control over the thr, leu, and ilv operons of Escherichia coli K-12. PubMed: Rapid enzymatic preparation of [14C]D-leucine from [14C]DL-leucine. PubMed: The radiolysis and racemization of leucine on proton irradiation. PubMed: Search for effect of longitudinally polarized protons on optically active amino acid. PubMed: Liver microsomal drug-metabolizing enzyme activity: enhancement by blockade of degradative processes in promethazine-treated rats. PubMed: The radiolysis of tryptophan and leucine with 32P beta-radiation. PubMed: Th activities of perfused livers of control and streptozotocin diabetic rats in the synthesis of some plasma proteins and peptides. PubMed: [Effect of raised temperatures on the protein and RNA synthesis rate in yeasts]. PubMed: [Effect of increased temperatures on RNA and protein synthesis in the cells of a synchronous Candida utilis culture]. PubMed: [Synthesis of amino acid antipyrine-4-amides. II. 4-antipyrinamides of DL-leucine, phenylalanine, tyrosine, glutaminic acid and epsilon-aminocaproic acid]. PubMed: Asymmetric degradation of DL-leucine with longitudinally polarised electrons. PubMed: Asymmetric degradation of DL-leucine with longitudinally polarised electrons. PubMed: Raman spectra of D and L amino acid copolymers. Poly-DL-alanine, poly-DL-leucine, and poly-DL-lysine. PubMed: Distribution of lactic dehydrogenase in X-irradiated tissues. PubMed: Differences in the incorporation of L- and DL-Amino acids into renal tubular cells. An autoradiographic study. PubMed: Regulation of leucine catabolism in Pseudomonas putida. PubMed: New amino acid regulatory locus having unusual properties in heterozygous merodiploids. PubMed: Oxidation of DL-3-phenylalanine-1- 14 C, DL-leucine-1- 14 C, and D-glucose-1- 14 C-6-phosphate to 14 CO 2 in human placenta. PubMed: [Incorporation in vitro of DL-leucine-1-C14 into proteins of the rat liver, kidney and diaphragm in presence of various concentrations of albumin]. PubMed: [Incorporation in vitro of DL-leucine-1-C14 into the proteins of the cells of Yoshida's ascites hepatoma and of ascitic sarcoma 180 in presence of various concentrations of albumin]. PubMed: Regulation of branched-chain amino acid biosynthesis in Salmonella typhimurium: isolation of regulatory mutants. PubMed: Effect of steroid hormones on dl-leucine-1-14C uptake by the uterus of pregnant rats maintained on a protein-free diet. PubMed: Uptake of 3-H-DL-leucine and 3-H-uridine by the caudal neurosecretory system of the loach (Misgurnus anguillicaudatus) maintained in vitro. PubMed: [Studies on the dependency upon radiation dose of microwaves saturation in electron spin resonance radiation-induced free radicals of DL-valine and DL-leucine]. PubMed: Liver adenine nucleotides: fructose-induced depletion and its effect on protein synthesis. PubMed: [Quantitative study by radioautography and electron microscopy of the utilization of DL-leucine-H3 by duck hypophyseal cells in organ culture]. PubMed: Protein biosynthesis in trypanosomidae. II. The metabolic fate of DL-leucine-1-C14 in Trypanosoma cruzi. PubMed: PROTEIN SYNTHESIS, STORAGE, AND DISCHARGE IN THE PANCREATIC EXOCRINE CELL. AN AUTORADIOGRAPHIC STUDY. PubMed: IN VIVO AND IN VITRO EFFECT OF GLUCAGON DL-LEUCINE-1-C14 INCORPORATION INTO PROTEIN OF RAT PANCREAS. PubMed: STUDIES ON THE METABOLISM OF THE RETINA AND LATERAL GENICULATE NUCLEUS. IN VIVO INCORPORATION OF H-3-DL-LEUCINE IN ALBINO RATS. PubMed: Biosynthesis of chloramphenicol. IV. Incorporation of carbon 14-labled precursors. PubMed: Studies on the metabolic function of branched-chain volatile fatty acids, growth factors for ruminococci. I. Incorporation of isovalerate into leucine. PubMed: Physiological studies of the rumen protozoan Ophryoscolex caudatus Eberlein. PubMed: [Experimental research on the behavior of vestibular function after the administration of certain drugs. II. Acetyl-DL-leucine]. PubMed: A cytochemical study on the pancreas of the guinea pig. 5. In vivo incorporation of leucine-1-C14 into the chymotrypsinogen of various cell fractions. PubMed: [Incorporation of tritium-labeled DL-leucine into the blood cells in acute leukosis and in chronic myeloid leukemia]. PubMed: [Data on protein metabolism in normal bone marrow. Incorporation of tritium-labeled DL-leucine and tritium-labeled DL-beta-phenylalanine]. PubMed: Effects of thyroxin on amino acid incorporation into protein. PubMed: A cyto-chemical study on the pancreas of the guinea pig. III. In vivo incorporation of leucine-1-C14 into the proteins of cell fractions. PubMed: [Trial therapy of labyrinthine vertigo by acetyl-DL-leucine]. PubMed: In vitro incorporation of C14-DL-leucine into normal and leukemic white cells. PubMed: Acylchlorides of amino acids and peptides as monomers for the preparation of polymeric polypeptides. I. Syntheses of poly-beta-alanine, poly-DL-alanine, poly-L-leucine and poly-glycyl-DL-leucine. PubMed: PLASMA PROTEIN PRODUCTION INFLUENCED BY AMINO ACID MIXTURES AND LACK OF ESSENTIAL AMINO ACIDS : A DEFICIENCY STATE RELATED TO UNKNOWN FACTORS.