2-methyl piperidine

2-methylpiperidine

CAS: 109-05-7 C6 H13 N MW: 99.17661000 ammoniacal ammoniacal

Identification

Name2-methyl piperidine
IUPAC2-methylpiperidine
CAS Number109-05-7
EINECS203-642-1
FDA UNII22E509663B
Molecular FormulaC6 H13 N
Molecular Weight99.17661000
MDL NumberMFCD00005982
Nikkaji NumberJ5.086E
Beilstein0079804

Regulatory

JECFA Food Flavoring1608 2-methylpiperidine
DG SANTE Food Flavourings14.133 2-methylpiperidine
FEMA Number4244
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)109-05-7 ; 2-METHYLPIPERIDINE

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.83800 to 0.84400 @ 25.00 °C.
Pounds per Gallon - (est). 6.973 to 7.023
Refractive Index 1.44200 to 1.44800 @ 20.00 °C.
Boiling Point 117.00 to 119.00 °C. @ 760.00 mm Hg
Vapor Pressure 16.395000 mmHg @ 25.00 °C. (est)
Flash Point 50.00 °F. TCC ( 10.00 °C. )
logP (o/w) 1.148 (est)
Soluble in alcohol

Organoleptic Properties

Odor Strength high ,
Substantivity 2 hour(s) at 1.00 % in propylene glycol
Odor Description at 1.00 % in propylene glycol.
Odor sample from Sigma-Aldrich
Taste Description at 5.00 ppm in water.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral ToxicityNot determined
Dermal Toxicitysubcutaneous-rabbit LDLo 300 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for 2-methyl piperidine usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)0.002 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)340 (μg/person/day)
Threshold of Concern540 (μg/person/day)
Structure ClassII
baked goods2.00000
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal0.20000
cheese0.40000
chewing gum-
condiments / relishes0.10000
confectionery froastings1.00000
egg products-
fats / oils0.10000
fish products0.20000
frozen dairy0.40000
fruit ices0.40000
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products0.20000
milk products0.40000
nut products-
other grains0.20000
poultry0.20000
processed fruits0.40000
processed vegetables-
reconstituted vegetables-
seasonings / flavors0.10000
snack foods1.00000
soft candy-
soups0.10000
sugar substitutes-
sweet sauces-
Dairy products, excluding products of category 02.0 (01.0)0.40000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)0.10000
Edible ices, including sherbet and sorbet (03.0)0.40000
Processed fruit (04.1)0.40000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)1.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)0.20000
Bakery wares (07.0)2.00000
Meat and meat products, including poultry and game (08.0)0.20000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)0.20000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)0.10000
Foodstuffs intended for particular nutritional uses (13.0)0.20000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)-
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)1.00000
Ready-to-eat savouries (15.0)1.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)0.20000

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Potential Uses

FL cereal FL cheese FL corn chip FL fish FL seafood

Natural Occurrence

beef roasted beef PMC

Synonyms

(±)-2- methyl piperidine alpha- methyl piperidine dextro,laevo-2- methyl piperidine 2- methyl-piperidine (R,S)-2- methylpiperidine 2- methylpiperidine DL-2- methylpiperidine (±)-alpha- pipecoline 2- pipecoline a- pipecoline alpha- pipecoline pipecoline, a piperidine, 2-methyl- Info: aliphatic and aromatic amines and amides derivatives PubMed: Palladium-catalyzed one-pot three- or four-component coupling of aryl iodides, alkynes, and amines through C-N bond cleavage: efficient synthesis of indole derivatives. PubMed: An Fmoc compatible, O to S shift-mediated procedure for the preparation of C-terminal thioester peptides. PubMed: Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells. PubMed: Intramolecular aminoalkene hydroamination mediated by a tethered bis(ureate)zirconium complex: computational perusal of various pathways for aminoalkene activation. 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PubMed: Release of nitric oxide from novel diazeniumdiolates monitored by laser magnetic resonance spectroscopy. PubMed: Stereochemical effects in an insect repellent. PubMed: Field evaluation of repellents containing deet and AI3-37220 against Anopheles koliensis in Papua New Guinea. PubMed: Field evaluation of deet and a piperidine repellent against Aedes communis (Diptera: Culicidae) and Simulium venustum (Diptera: Simuliidae) in the Adirondack Mountains of New York. PubMed: Laboratory evaluation of AI3-37220, AI3-35765, CIC-4, and deet repellents against three species of mosquitoes. PubMed: Field evaluation of the repellents deet, CIC-4, and AI3-37220 against Anopheles in Lae, Papua New Guinea. PubMed: Short report: prevention of Schistosoma mansoni infections in mice by the insect repellents AI3-37220 and N,N-diethyl-3-methylbenzamide. PubMed: Laboratory and field evaluation of the repellents deet, CIC-4, and AI3-37220 against Anopheles farauti (Diptera: Culicidae) in Australia. PubMed: Increase of mucous glycoprotein secretion by tumor necrosis factor alpha via a protein kinase C-dependent mechanism in cultured chinchilla middle ear epithelial cells. PubMed: Laboratory and field evaluation of deet, CIC-4, and AI3-37220 against Anopheles dirus (Diptera: Culicidae) in Thailand. PubMed: Field evaluation of arthropod repellents, deet and a piperidine compound, AI3-37220, against Anopheles funestus and Anopheles arabiensis in western Kenya. PubMed: Laboratory tests of arthropod repellents against Leptotrombidium deliense--noninfected and infected with Rickettsia tsutsugamushi--and noninfected L. fletcheri (Acari: Trombiculidae). PubMed: Laboratory and field evaluation of five repellents against the black flies Prosimulium mixtum and P. fuscum (Diptera: Simuliidae). PubMed: Opioid and nicotinic medullary hyperalgesic influences in the decerebrated rat. PubMed: Interactions of piperidine derivatives with the nicotinic cholinergic receptor complex from Torpedo electric organ. PubMed: Effects of the protein kinase C inhibitor H-7 and calmodulin antagonist W-7 on superoxide production in growing and resting human histiocytic leukemia cells (U937). PubMed: Fourth ventricle effects of nicotine, 2-methylpiperidine and cytisine in dogs. PubMed: Stereospecificity of 2-methylpiperidine binding to a nicotinic up-regulatory site in the rat brain P2 preparation. PubMed: Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation. PubMed: Studies on pyrazine derivatives. Part X. Synthesis and tuberculostatic activity of some 6-cyclamino-, 6-imidazolyl--and triazolylpyrazine-2-carboxylic acids derivatives. PubMed: [Synthesis of N-(beta-ethoxyethyl)-2-methylpiperidine]. PubMed: The use of 2-pipecoline in the Mannich reaction.