2-nonanone

methyl heptyl ketone

CAS: 821-55-6 C9 H18 O MW: 142.24166000 fruity cheesy

Identification

Name2-nonanone
IUPACnonan-2-one
CAS Number821-55-6
EINECS212-480-0
FDA UNIIZE5K73YN2Z
Molecular FormulaC9 H18 O
Molecular Weight142.24166000
MDL NumberMFCD00009553
Nikkaji NumberJ7.123D
Beilstein1743645
CoE Number154
XlogP33.10 (est)

Regulatory

JECFA Food Flavoring292 2-nonanone
DG SANTE Food Flavourings07.020 nonan-2-one
FEMA Number2785
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)821-55-6 ; 2-NONANONE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless to pale yellow clear oily liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed Yes
Specific Gravity 0.81700 to 0.82300 @ 25.00 °C.
Pounds per Gallon - (est). 6.798 to 6.848
Refractive Index 1.41800 to 1.42300 @ 20.00 °C.
Melting Point -21.00 °C. @ 760.00 mm Hg
Boiling Point 192.00 °C. @ 743.00 mm Hg, 194.00 to 196.00 °C. @ 760.00 mm Hg
Acid Value 1.00 max. KOH/g
Vapor Pressure 0.645000 mmHg @ 25.00 °C. (est)
Flash Point 148.00 °F. TCC ( 64.44 °C. )
logP (o/w) 3.140
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength medium
Substantivity > 4 hour(s) at 100.00 %
Odor Description
at 100.00 %.
Fruity, sweet, waxy, soapy, cheese, green herbaceous, coconut like
fresh sweet, weedy, earthy, herbal
fresh sweet green weedy earthy herbal
Taste Description
fruity, cheesy
at 20.00 ppm.
Fermented, generic cheese notes
Typical blue cheese with mushroom nuances at higher dosage fatty and fruity nuances at lower dosage
green fruity, dairy, cheesy, buttery

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 3200 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation Toxicityinhalation-rat LC50 > 3980 mg/m3/6H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for 2-nonanone usage levels up to3.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)320.00 (μg/capita/day)
baked goods0.40000
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy0.10000
fruit ices0.10000
gelatins / puddings-
granulated sugar-
gravies-
hard candy0.40000
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

Advanced Biotech. Inc.

Inspired by Nature

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Alfrebro LLC/ Archer Daniels Midland Company

Let's get reacquainted

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Associate Allied Chemicals

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Augustus Oils Ltd

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Axxence Aromatic GmbH

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Bedoukian Research, Inc.

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Beijing Lys Chemicals Co, LTD.

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Extensive Line

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Excellentia International

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Firmenich Inc.

We Create

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View All Website +1 609 452 1000 Frederick.Keifer@firmenich.com

Fleurchem, Inc.

Have A Flavorful Day

A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.

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Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Global Essence Inc.

Preferred Partner

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Indukern, S.A. F&F Ingredients Division

Commitment to quality

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View All Website +34 93 506 91 00 info@indukern.es

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

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View All Website 86-510-86023169 info@healthwaychem.com

Lluch Essence S.L.

A family company dedicated to sales and distribution

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View All Website 34 93 379 38 49 web@lluche.com

M&U International LLC

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Moellhausen S.P.A.

THE CHEMISTRY OF EMOTIONS

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Natural Advantage

Manufacturer of natural flavor ingredients

With over 25 years experience in the flavor and food ingredient industries.

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Odowell Co.,ltd

Fulfilling Demand

Product quality and consistency.

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Penta International Corporation

Chemistry innovation

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Sigma-Aldrich

Complete Supply Chain

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SRS Aromatics Ltd

For over 25 years

Bringing flavour and fragrance into your world.

View All Website +44 (0) 1284 704076 info@srsaromatics.co.uk

Synerzine, Inc.

Innovation. Customization. Aroma Ingredients.

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Taytonn ASCC Pte Ltd

Supplying Asia Pacific

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TCI AMERICA

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R C Treatt and Co Ltd

Innovative ingredient solutions

World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.

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Ernesto Ventós S.A.

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WholeChem, LLC

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Potential Uses

FR ash mountain ash FR butter FR carnation FL cheese cheddar cheese FR clove FR coconut FR earth FL fat FR green FR herbal FR lavender FR pineapple FR rose FR rose tea rose FL/FR rue FR strawberry

Natural Occurrence

beer PMC boldo leaf oil italy @ 0.10% Data boldus leaf oil chile @ 0.04% Data butter PMC carnation cascarilla bark oil @ 0.18% Data champaca concrete @ 0.02% Data cheese bleu cheese PMC cheese cheddar cheese PMC cheese gorgonzola cheese PMC clove bud clove fruit coconut corn husk oil corn seed oil corn silk curcuma amada roxb. rhizome oil india @ 0.10% Data fish PMC ginger rhizome ginger rhizome oil kachur oil @ 0.30% Data krill PMC laurel leaf oil turkey @ trace% Data mastic fruit oil @ 0.14% Data mastic leaf oil @ 1.71% Data potato chip PMC rice cooked rice PMC rosemary sap rue flower oil colombia @ 16.82% Data rue oil china @ 24.12% Data rue oil cuba @ 0.62% Data rue plant strawberry wild strawberry fruit sugandha kokila berry oil @ 1.90% Data tea leaf watermelon fruit juice

Synonyms

heptyl methyl ketone N- heptyl methyl ketone ketone, heptyl methyl methyl heptyl ketone methyl heptyl ketone (2-nonanone), natural methyl heptyl ketone natural nonan-2-one 2- nonanone beta- nonanone 2- nonanone (methyl heptyl ketone) natural 2- nonanone (natural) 2- nonanone natural Info: HEPTAN-2-ONE US Patents: 3,952,024 - Furfurylthioacetone PubMed: Synthesis of methyl ketones by metabolically engineered Escherichia coli. US Patents: 3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines PubMed: Quantification of volatile compounds in goat milk Jack cheese using static headspace gas chromatography. PubMed: Binding of flavor compounds and whey protein isolate as affected by heat and high pressure treatments. PubMed: Kinetic analysis of volatile formation in milk subjected to pressure-assisted thermal treatments. PubMed: Binding of 2-nonanone and milk proteins in aqueous model systems. PubMed: Quantitative determination of thermally derived off-flavor compounds in milk using solid-phase microextraction and gas chromatography. PubMed: Flavor production from a non-stick oil by moulds. PubMed: Interactions between methyl ketones and beta-lactoglobulin: sensory analysis, headspace analysis, and mathematical modeling. PubMed: A customized metal oxide semiconductor-based gas sensor array for onion quality evaluation: system development and characterization. PubMed: The dynamics of the HS/SPME-GC/MS as a tool to assess the spoilage of minced beef stored under different packaging and temperature conditions. PubMed: Influence of storage on volatile profiles in roasted almonds (Prunus dulcis). PubMed: Quantitative analysis of volatile organic compounds released and consumed by rat L6 skeletal muscle cells in vitro. PubMed: Characterization of volatiles of necrotic Stenocereus thurberi and Opuntia littoralis and toxicity and olfactory preference of Drosophila melanogster, D. mojavensis wrigleyi, and D. mojavensis sonorensis to necrotic cactus volatiles. PubMed: Determination of volatile compounds in turbot (Psetta maxima) during refrigerated storage by headspace solid-phase microextraction and gas chromatography-mass spectrometry. PubMed: Investigation of volatile metabolites during growth of Escherichia coli and Pseudomonas aeruginosa by needle trap-GC-MS. PubMed: Assessment of robustness on analysis using headspace solid-phase microextraction and comprehensive two-dimensional gas chromatography through experimental designs. PubMed: Analysis of volatile organic compounds liberated and metabolised by human umbilical vein endothelial cells (HUVEC) in vitro. PubMed: Inhibitory and toxic effects of volatiles emitted by strains of Pseudomonas and Serratia on growth and survival of selected microorganisms, Caenorhabditis elegans, and Drosophila melanogaster. PubMed: Characterization of important odorants in steamed male Chinese mitten crab (Eriocheir sinensis) using gas chromatography-mass spectrometry-olfactometry. PubMed: Biting deterrence, repellency, and larvicidal activity of Ruta chalepensis (Sapindales: Rutaceae) essential oil and its major individual constituents against mosquitoes. PubMed: Assessing the efficacy of candidate mosquito repellents against the background of an attractive source that mimics a human host. PubMed: Monodimensional (GC-FID and GC-MS) and comprehensive two-dimensional gas chromatography for the assessment of volatiles and fatty acids from Ruta chalepensis aerial parts. PubMed: Olfactory sensitivity and odor structure-activity relationships for aliphatic ketones in CD-1 mice. PubMed: Volatile composition and sensory properties of Indian herbal medicine-Pavonia odorata-used in Ayurveda. PubMed: Interactions of flavoured oil in-water emulsions with polylactide. PubMed: Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece. PubMed: Main individual and product characteristics influencing in-mouth flavour release during eating masticated food products with different textures: mechanistic modelling and experimental validation. PubMed: Nuclear PKG localization is regulated by G₀ alpha and is necessary in the AWB neurons to mediate avoidance in Caenorhabditis elegans. PubMed: Release and uptake of volatile organic compounds by human hepatocellular carcinoma cells (HepG2) in vitro. PubMed: Dissociation of proton bound ketone dimers in asymmetric electric fields with differential mobility spectrometry and in uniform electric fields with linear ion mobility spectrometry. PubMed: Can volatile organic metabolites be used to simultaneously assess microbial and mite contamination level in cereal grains and coffee beans? PubMed: Sensory interaction between attractant diacetyl and repellent 2-nonanone in the nematode Caenorhabditis elegans. PubMed: Mass and Ion Transport in Ketones and Ketone Electrolytes: Comparison with Acetate Systems. PubMed: Effect of storage time and heat processing on the volatile profile of Senegalese sole (Solea senegalensis Kaup, 1858) muscle. PubMed: Attractiveness of an aggregation pheromone lure and chicken droppings to adults and larvae of Alphitobius diaperinus (Coleoptera: Tenebrionidae). PubMed: Salt reduction in slow fermented sausages affects the generation of aroma active compounds. PubMed: Following butter flavour deterioration with an acoustic wave sensor. PubMed: Synthesis of methyl ketones by metabolically engineered Escherichia coli. PubMed: Molecular analysis of volatile metabolites released specifically by Staphylococcus aureus and Pseudomonas aeruginosa. PubMed: Effects of frozen storage and vacuum packaging on free fatty acid and volatile composition of Turkish Motal cheese. PubMed: Measuring gas-liquid partition coefficients of aroma compounds by solid phase microextraction, sampling either headspace or liquid. PubMed: Volatile biomarkers of Pseudomonas aeruginosa in cystic fibrosis and noncystic fibrosis bronchiectasis. PubMed: Control of postharvest Botrytis fruit rot of strawberry by volatile organic compounds of Candida intermedia. PubMed: Enhancement of odor avoidance regulated by dopamine signaling in Caenorhabditis elegans. PubMed: Novel platinum(II) complexes of 3-(aminomethyl)naphthoquinone Mannich bases: synthesis, crystal structure and cytotoxic activities. PubMed: Isolation and characterization of 4-tert-butylphenol-utilizing Sphingobium fuliginis strains from Phragmites australis rhizosphere sediment. PubMed: Transmembrane segment 3 of Drosophila melanogaster odorant receptor subunit 85b contributes to ligand-receptor interactions. PubMed: Quantification of volatile compounds in goat milk Jack cheese using static headspace gas chromatography. PubMed: Olfactory psychometric functions for homologous 2-ketones. PubMed: Male-produced aggregation pheromone of the lesser mealworm beetle, Alphitobius diaperinus. PubMed: Mesophilic and psychrotrophic bacteria from meat and their spoilage potential in vitro and in beef. PubMed: Binding of flavor compounds and whey protein isolate as affected by heat and high pressure treatments. PubMed: Multi-channel open tubular traps for headspace sampling, gas chromatographic fraction collection and olfactory assessment of milk volatiles. PubMed: Interactions between beta-lactoglobulin and aroma compounds: different binding behaviors as a function of ligand structure. PubMed: Relationship between sensory attributes and volatile compounds qualifying dry-cured hams. PubMed: Asthma arising in flavoring-exposed food production workers. PubMed: Chemical characterization of territorial marking fluid of male Bengal tiger, Panthera tigris. PubMed: Kinetic analysis of volatile formation in milk subjected to pressure-assisted thermal treatments. PubMed: Binding of 2-nonanone and milk proteins in aqueous model systems. PubMed: Active package for wild strawberry fruit (Fragaria vesca L.). PubMed: Effect of concentration and relative humidity on the transfer of alkan-2-ones through paper coated with wheat gluten. PubMed: Quantitative determination of thermally derived off-flavor compounds in milk using solid-phase microextraction and gas chromatography. PubMed: Assessment of monitoring methods for early detection of three species of storage mite in bulk oilseed rape. PubMed: Volatile organic compounds in natural biofilm in polyethylene pipes supplied with lake water and treated water from the distribution network. PubMed: Characterization of respiratory exposures at a microwave popcorn plant with cases of bronchiolitis obliterans. PubMed: The metabolism of nonane, a JP-8 jet fuel component, by human liver microsomes, P450 isoforms and alcohol dehydrogenase and inhibition of human P450 isoforms by JP-8. PubMed: Expeditious asymmetric synthesis of a stereoheptad corresponding to the C(19)-C(27)-ansa chain of rifamycins: formal total synthesis of Rifamycin S. PubMed: Evidence for pi-pi electron donor-acceptor interactions between pi-donor aromatic compounds and pi-acceptor sites in soil organic matter through pH effects on sorption. PubMed: Olfactory sensitivity for aliphatic ketones in squirrel monkeys and pigtail macaques. PubMed: Volatiles in a sausage surface model-influence of Penicillium nalgiovense, Pediococcus pentosaceus, ascorbate, nitrate and temperature. PubMed: Analysis of ketones by selected ion flow tube mass spectrometry. PubMed: Odorants in breast milk. PubMed: Otx/otd homeobox genes specify distinct sensory neuron identities in C. elegans. PubMed: Chemistry, ontogeny, and role of pygidial gland secretions of the vinegaroon Mastigoproctus giganteus (Arachnida: Uropygi). PubMed: Influence of lipophilicity on the interactions of N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and their positively charged N-alkyl-4-phenylpyridinium metabolites with cytochrome P450 2D6. PubMed: Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. PubMed: In vitro efficacy of plant volatiles for inhibiting the growth of fruit and vegetable decay microorganisms. PubMed: Resistance to 2-tridecanone in Tetranychus urticae: effects of induced resistance, cross-resistance and heritability. PubMed: Rhodium carboxylate catalyzed decomposition of vinyldiazoacetates in the presence of heterodienes: enantioselective synthesis of the 6-azabicyclo[3.2.2]nonane and 6-azabicyclo[3.2.2]nonanone ring systems. PubMed: Chemosignalling of musth by individual wild African elephants (Loxodonta africana): implications for conservation and management. PubMed: Flavor production from a non-stick oil by moulds. PubMed: Effect of meso-substituents on the osmium tetraoxide reaction and pinacol-pinacolone rearrangement of the corresponding vic-dihydroxyporphyrins. PubMed: Volatile compounds released during ripening in Italian dried sausage. PubMed: Volatile sulfur production by pig cecal bacteria in batch culture and screening inhibitors of sulfate reducing bacteria. PubMed: Interactions between methyl ketones and beta-lactoglobulin: sensory analysis, headspace analysis, and mathematical modeling. PubMed: High-resolution gas-chromatographic analysis of the secondary metabolites obtained by subcritical-fluid extraction from Colombian rue (Ruta graveolens L.). PubMed: Odour-impact compounds of Gorgonzola cheese. PubMed: A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans. PubMed: Volatile compounds from Escherichia coli O157:H7 and their absorption by strawberry fruit. PubMed: Transfer of aroma compounds in water-lipid systems: binding tendency of beta-lactoglobulin. PubMed: Interactions between aroma and edible films. 1. Permeability Of methylcellulose and low-density polyethylene films to methyl ketones. PubMed: Reptilian chemistry: characterization of dianeackerone, a secretory product from a crocodile. PubMed: Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C. elegans. PubMed: Relative sensitivity of the ocular trigeminal, nasal trigeminal and olfactory systems to airborne chemicals. PubMed: Volatile organic chemicals of a shore-dwelling cyanobacterial mat community. PubMed: Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. PubMed: Effects of several selected odorants on the sodium- and potassium-dependent adenosine triphosphatase activities of two different chicken olfactory tuberinals. PubMed: Chemical analysis of temporal gland secretions collected from an Asian bull elephant during a four-month musth episode. PubMed: Volatile methyl ketone seed-germination inhibitors fromAmaranthus palmeri S. Wats. Residues. PubMed: Observations concerning the nature of sites of anaesthetic action in Gammarus. PubMed: Volatiles of Pseudomonas aeruginosa and related species by automated headspace concentration--gas chromatography. PubMed: Anaesthetic action of esters and ketones: evidence for an interaction with the sodium channel protein in squid axons. PubMed: Odorous chemical perturbations of (Na+ + K+)-dependent ATPase activities. Effects on native and lipid-substituted preparations from individual turbinals from dog olfactory tissue. PubMed: Commercial-grade methyl heptyl ketone (5-methyl-2-octanone) neurotoxicity: contribution of 5-nonanone. PubMed: The neurotoxicity of 5-nonanone: preliminary report. PubMed: Headspace analysis of volatile metabolites of Pseudomonas aeruginosa and related species by gas chromatography-mass spectrometry. PubMed: Stabilization of proteins by solvents. Effect of pH and anions on the positive cooperativity of 2-nonanone binding to bovine serum albumin. PubMed: [Gas-chromatographic-mass-spectral analysis of aroma-compounds of bread (author's transl)]. PubMed: A novel ketone monooxygenase from Pseudomonas cepacia. Purification and properties.