(+)-boldine

aprophine alkaloid (S)- boldine boldine-chloroform 4H- dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)- 4H- dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (S)- 4H- dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)- 4H- dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (S)- (9S)-4,16- dimethoxy-10-methyl-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,13,15-hexaene-5,15-diol (6aS)-1,10- dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol (S)-1,10- dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol PubMed: [Behavioural impairments and hallucinations after consumption of boldo leaf infusions]. PubMed: A novel UPLC-MS/MS method for sensitive quantitation of boldine in plasma, a potential anti-inflammatory agent: application to a pharmacokinetic study in rats. PubMed: Surface enhanced Raman scattering study of the antioxidant alkaloid boldine using prismatic silver nanoparticles. PubMed: Immunomodulatory effect of an isolated fraction from Tinospora crispa on intracellular expression of INF-γ, IL-6 and IL-8. PubMed: Natural products as potential human ether-a-go-go-related gene channel inhibitors - screening of plant-derived alkaloids. PubMed: Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models. PubMed: Antiplasmodial and antioxidant isoquinoline alkaloids from Dehaasia longipedicellata. PubMed: Natural compounds boldine and menthol are antagonists of human 5-HT3 receptors: implications for treating gastrointestinal disorders. PubMed: Boldine and related aporphines: from antioxidant to antiproliferative properties. PubMed: Boldine prevents renal alterations in diabetic rats. PubMed: Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT, and GSK-3β. PubMed: Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II-mediated BMP4-oxidative stress cascade. PubMed: Development of an HPLC fluorescence method for determination of boldine in plasma, bile and urine of rats and identification of its major metabolites by LC-MS/MS. PubMed: Batch and Continuous Ultrasound Assisted Extraction of Boldo Leaves (Peumus boldus Mol.). PubMed: Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism. PubMed: Applied biological and physicochemical activity of isoquinoline alkaloids: oxoisoaporphine and boldine. PubMed: Acetylcholinesterase inhibition, antioxidant activity and toxicity of Peumus boldus water extracts on HeLa and Caco-2 cell lines. PubMed: (-)-Kunstleramide, a new antioxidant and cytotoxic dienamide from the bark of Beilschmiedia kunstleri gamble. PubMed: The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats. PubMed: Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species. PubMed: Alkaloids from the Chinese vine Gnetum montanum. PubMed: Boldo prevents UV light and nitric oxide-mediated plasmid DNA damage and reduces the expression of Hsp70 protein in melanoma cancer cells. PubMed: (+)-Kunstlerone, a new antioxidant neolignan from the Leaves of Beilschmiedia kunstleri gamble. PubMed: Lancifoliaine, a new bisbenzylisoquinoline from the bark of Litsea lancifolia. PubMed: In vitro cytotoxic evaluation of a novel phosphinyl derivative of boldine. PubMed: New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumoniae. PubMed: Cytotoxic thiocarbamate derivatives of boldine. PubMed: Quantitative analysis of boldine alkaloid in natural extracts by cyclic voltammetry at a liquid-liquid interface and validation of the method by comparison with high performance liquid chromatography. PubMed: Direct identification of phenolic constituents in Boldo Folium (Peumus boldus Mol.) infusions by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry. PubMed: The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells. PubMed: (+)-N-(2-hydroxypropyl)lindcarpine: a new cytotoxic aporphine isolated from Actinodaphne pruinosa Nees. PubMed: [Simultaneous determination of four alkaloids in Lindera aggregate by high performance liquid chromatography]. PubMed: Alkaloids from Lindera aggregata. PubMed: Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis. PubMed: Effect of boldo (Peumus boldus Molina) infusion on lipoperoxidation induced by cisplatin in mice liver. PubMed: Boldine: a potential new antiproliferative drug against glioma cell lines. PubMed: Simultaneous determination of four alkaloids in Lindera aggregata by ultra-high-pressure liquid chromatography-tandem mass spectrometry. PubMed: 5-Hydroxytryptamine2A receptor binding activity of compounds from Litsea sessilis. PubMed: Antioxidant and pro-oxidant properties of boldine on hippocampal slices exposed to oxygen-glucose deprivation in vitro. PubMed: Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. PubMed: Characterization of isoquinoline alkaloids from Neolitsea sericea var. aurata by HPLC-SPE-NMR. PubMed: Studies of Genetic Variation of Essential Oil and Alkaloid Content in Boldo (Peumus boldus). PubMed: Advances in development of dopaminergic aporphinoids. PubMed: Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction. PubMed: Antihyperglycemic effect of aporphines and their derivatives in normal and diabetic rats. PubMed: Sensitive quantification of apomorphine in human plasma using a LC-ESI-MS-MS method. PubMed: Antinociceptive and free radical scavenging activities of alkaloids isolated from Lindera angustifolia Chen. PubMed: [Alkaloids from the root of Lindera angustifolia]. PubMed: 8-NH2-boldine, an antagonist of alpha1A and alpha1B adrenoceptors without affinity for the alpha1D subtype: structural requirements for aporphines at alpha1-adrenoceptor subtypes. PubMed: Boldine and its antioxidant or health-promoting properties. PubMed: Photostability and photoprotection factor of boldine and glaucine. PubMed: Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo. PubMed: Structure-affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: halogenation and D1 receptor selectivity. PubMed: Cytotoxic and antitumor potentialities of aporphinoid alkaloids. PubMed: Photochemistry of phytoalexins containing phenalenone-like chromophores: photophysics and singlet oxygen photosensitizing properties of the plant oxoaporphine alkaloid oxoglaucine. PubMed: Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine. PubMed: Alkaloids from Cassytha filiformis and related aporphines: antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases. PubMed: A novel alkaloid antioxidant, Boldine and synthetic antioxidant, reduced form of RU486, inhibit the oxidation of LDL in-vitro and atherosclerosis in vivo in LDLR(-/-) mice. PubMed: Inhibitory action of conventional food-grade natural antioxidants and of natural antioxidants of new development on the thermal-induced oxidation of cholesterol. PubMed: Spectroscopic study of antileishmanial drug incubated in the promastigotes of Leishmania mexicana. PubMed: Sipaucins A-C, sesquiterpenoids from Siparuna pauciflora. PubMed: Free-radical scavengers and antioxidants from Peumus boldus Mol. ("Boldo"). PubMed: Effects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice. PubMed: Protection against UVB irradiation by natural filters extracted from lichens. PubMed: Affinity profile at alpha(1)- and alpha(2)-adrenoceptor subtypes and in vitro cardiovascular actions of (+)-boldine. PubMed: Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity. PubMed: Protective effect of boldine on dopamine-induced membrane permeability transition in brain mitochondria and viability loss in PC12 cells. PubMed: Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes. PubMed: Release of intermediate reactive hydrogen peroxide by macrophage cells activated by natural products. PubMed: Free-radical-induced inactivation of lysozyme and carbonyl residue generation in protein are not necessarily associated. PubMed: Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats. PubMed: Protective effects of boldine against free radical-induced erythrocyte lysis. PubMed: Biological disposition of boldine: in vitro and in vivo studies. PubMed: Halogenated boldine derivatives with enhanced monoamine receptor selectivity. PubMed: Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. PubMed: Boldine action against the stannous chloride effect. PubMed: Dry plant extracts loaded on fumed silica for direct compression: preparation and preformulation. PubMed: Halogenated derivatives of boldine with high selectivity for alpha1A-adrenoceptors in rat cerebral cortex. PubMed: Biochemical and behavioral effects of boldine and glaucine on dopamine systems. PubMed: Glaucine analogues as inhibitors of mouse splenocyte activity. PubMed: Antipoliovirus structure-activity relationships of some aporphine alkaloids. PubMed: Studies on neuromuscular blockade by boldine in the mouse phrenic nerve-diaphragm. PubMed: Effects of boldine on mouse diaphragm and sarcoplasmic reticulum vesicles isolated from skeletal muscle. PubMed: Inhibition of eukaryote protein kinases by isoquinoline and oxazine alkaloids. PubMed: Protective effect of boldine in experimental colitis. PubMed: Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. PubMed: A possible structural determinant of selectivity of boldine and derivatives for the alpha 1A-adrenoceptor subtype. PubMed: The effect of S-(+)-boldine on the alpha 1-adrenoceptor of the guinea-pig aorta. PubMed: Determination of lauraceous aporphine alkaloids by high-performance liquid chromatography. PubMed: Novel liquid chromatographic assay for the low-level determination of apomorphine in plasma. PubMed: Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes. PubMed: Antiplatelet and vasorelaxing actions of some aporphinoids. PubMed: The inhibitory effects of boldine, glaucine, and probucol on TPA-induced down regulation of gap junction function. Relationships to intracellular peroxides, protein kinase C translocation, and connexin 43 phosphorylation. PubMed: Boldine prevents human liver microsomal lipid peroxidation and inactivation of cytochrome P4502E1. PubMed: Structure-antioxidative activity relationships in benzylisoquinoline alkaloids. PubMed: Anti-inflammatory and antipyretic effects of boldine. PubMed: Mechanisms of vasorelaxation induced by N-allylsecoboldine in rat thoracic aorta. PubMed: Effects of boldine on cellular immune functions in vitro. PubMed: Evaluation of the genotoxic potential of the alkaloid boldine in mammalian cell systems in vitro and in vivo. PubMed: Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi. PubMed: Determination of boldine in drug formulations by first-derivative synchronous spectrofluorimetry. PubMed: Boldo and boldine: an emerging case of natural drug development. PubMed: Iron-reducing and free-radical-scavenging properties of apomorphine and some related benzylisoquinolines. PubMed: Different mechanism of relaxation induced by aporphine alkaloids in rat uterus. PubMed: Determination of boldine in plasma by high-performance liquid chromatography. PubMed: Selective action of two aporphines at alpha 1-adrenoceptors and potential-operated Ca2+ channels. PubMed: Antioxidant action of benzylisoquinoline alkaloids. PubMed: Inhibition of rat liver microsomal lipid peroxidation by boldine. PubMed: Inhibition of nonenzymic lipid peroxidation by benzylisoquinoline alkaloids. PubMed: Activity of boldine on rat ileum. PubMed: Genotoxicity of the boldine aporphine alkaloid in prokaryotic and eukaryotic organisms. PubMed: Antioxidant properties of the alkaloid boldine in systems undergoing lipid peroxidation and enzyme inactivation. PubMed: Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile, Peumus boldus. PubMed: Genotoxic effect of alkaloids. PubMed: A study of the adrenergic activity of the alkaloids boldine and glaucine. PubMed: Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, corytuberine, boldine and glaucine. PubMed: Alkaloids of Litsea wightiana1. PubMed: Voltammetric study of boldine on stationary platinum electrode. PubMed: Toxic alkaloids and their interaction with microsomal cytochrome P-450 in vitro. PubMed: [Determination of boldine by HPLC (high pressure liquid chromatography) in Boldus extracts]. PubMed: Biosynthesis of boldine (1,10-dimethoxy-6aalpha-aporphine-2,9-diol). PubMed: Fluorimetric analysis of alkaloids. Determination of serpentine, yohimbine, and boldine. PubMed: Stereochemical preferences for curarimimetic neuromuscular junction blockade I: enantiomeric monoquaternary amines as probes. PubMed: [Densitometric determination of boldine in boldo extracts]. PubMed: [Determination of boldine in Folium boldo and in the commercial preparation Boldiné Houdé]. PubMed: [A colored reaction of boldine]. PubMed: [Colorimetric determination of boldine].