silybin

4H-1- benzopyran-4-one, 2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- (2R,3R)-2-((2R,3R)-2,3- dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one [2R-[2a,3b,6(2R*,3R*)]]-2-[2,3- dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one dura-silymarin flavobin silibinin silliver silybum substance E6 silymarin (2R,3R)-3,5,7- trihydroxy-2-((2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one (2R,3R)-3,5,7- trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl]-chroman-4-one (2R,3R)-3,5,7- trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one (2R,3R)-3,5,7- trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one PubMed: Taurine Attenuates Hepatic Inflammation in Chronic Alcohol-Fed Rats Through Inhibition of TLR4/MyD88 Signaling. PubMed: Hepatopathy following consumption of a commercially available blue-green algae dietary supplement in a dog. PubMed: Silymarin and lycopene administration in periparturient dairy cows: effects on milk production and oxidative status. PubMed: Effects of aqueous extract of Withania somnifera on some liver biochemical and histopathological parameters in male guinea pigs. PubMed: Self-nanoemulsifying drug delivery systems ameliorate the oral delivery of silymarin in rats with Roux-en-Y gastric bypass surgery. PubMed: High-performance thin-layer chromatography linked with (bio)assays and mass spectrometry - a suited method for discovery and quantification of bioactive components? Exemplarily shown for turmeric and milk thistle extracts. PubMed: Effects of Silybum marianum (L.) Gaertn. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. PubMed: Silybum marianum: Beyond Hepatoprotection. PubMed: Silibinin mitigates zidovudine-induced hepatocellular degenerative changes, oxidative stress and hyperlipidaemia in rats. PubMed: Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity. PubMed: Blockade of lipid accumulation by silibinin in adipocytes and zebrafish. PubMed: A comparative study on the therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on D-GaIN/TNF-α-induced liver damage in Balb/c mice. PubMed: A novel approach for the efficient extraction of silybin from milk thistle fruits. PubMed: CCl4 induced genotoxicity and DNA oxidative damages in rats: hepatoprotective effect of Sonchus arvensis. PubMed: Silymarin in liposomes and ethosomes: pharmacokinetics and tissue distribution in free-moving rats by high-performance liquid chromatography-tandem mass spectrometry. PubMed: Antioxidant and protective effect of inulin and catechin grafted inulin against CCl4-induced liver injury. PubMed: Protective effects of Cholestin on ethanol induced oxidative stress in rats. PubMed: Attenuation of anti-tuberculosis therapy induced hepatotoxicity by Spirulina fusiformis, a candidate food supplement. PubMed: Silymarin inhibits the progression of fibrosis in the early stages of liver injury in CCl₄-treated rats. PubMed: Serum oxidative stress markers and lipidomic profile to detect NASH patients responsive to an antioxidant treatment: a pilot study. PubMed: Hepatoprotective effect of silymarin on di(2-ethylhexyl)phthalate (DEHP) induced injury in liver FL83B cells. PubMed: Silybum marianum oil attenuates oxidative stress and ameliorates mitochondrial dysfunction in mice treated with D-galactose. PubMed: Phyto-liposomes as nanoshuttles for water-insoluble silybin-phospholipid complex. PubMed: Colostrum yield and piglet growth during lactation are related to gilt metabolic and hepatic status prepartum. PubMed: Hepatoprotective activity of the neem-based constituent azadirachtin-A in carbon tetrachloride intoxicated Wistar rats. PubMed: Silibinin attenuates MPP⁺-induced neurotoxicity in the substantia nigra in vivo. PubMed: Hepatoprotective effect of polyphenols rich methanolic extract of Amorphophallus commutatus var. wayanadensis against CCl4 induced hepatic injury in swiss albino mice. PubMed: Effects of the plant extract silymarin on prolactin concentrations, mammary gland development, and oxidative stress in gestating gilts. PubMed: The role of milk thistle extract in breast carcinoma cell line (MCF-7) apoptosis with doxorubicin. PubMed: Antioxidant, anti-inflammatory and hepatoprotective effects of silymarin on hepatic dysfunction induced by sodium nitrite. PubMed: Hepatoprotective role of Nicotiana plumbaginifolia Linn. against carbon tetrachloride-induced injuries. PubMed: Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells. PubMed: Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer. PubMed: Protective effect of cordycepin-enriched Cordyceps militaris on alcoholic hepatotoxicity in Sprague-Dawley rats. PubMed: Effects of yam peel extract against carbon tetrachloride-induced hepatotoxicity in rats. PubMed: Antiosteoclastic activity of milk thistle extract after ovariectomy to suppress estrogen deficiency-induced osteoporosis. PubMed: Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression. PubMed: Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation. PubMed: Silibinin inhibits tumor growth through downregulation of extracellular signal-regulated kinase and Akt in vitro and in vivo in human ovarian cancer cells. PubMed: Antioxidant, free radical scavenging and liver protective effects of friedelin isolated from Azima tetracantha Lam. leaves. PubMed: Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes. PubMed: Biosafety and antioxidant effects of a beverage containing silymarin and arginine. A pilot, human intervention cross-over trial. PubMed: Chemical composition and biological evaluation of Physalis peruviana root as hepato-renal protective agent. PubMed: Protective effect of silymarin against ethanol-induced gastritis in rats: role of sulfhydryls, nitric oxide and gastric sensory afferents. PubMed: Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats. PubMed: Antihepatotoxic activity of a quantified Desmodium adscendens decoction and D-pinitol against chemically-induced liver damage in rats. PubMed: Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats. PubMed: Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro. PubMed: Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L. PubMed: Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats. PubMed: Potential antioxidant properties and hepatoprotective effects of an aqueous extract formula derived from three Chinese medicinal herbs against CCl(4)-induced liver injury in rats. PubMed: Absorption and metabolism of milk thistle flavanolignans in humans. PubMed: The use of galactogogues in the breastfeeding mother. PubMed: Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats. PubMed: Silymarin decreases connective tissue growth factor to improve liver fibrosis in rats treated with carbon tetrachloride. PubMed: Hepatoprotection with a chloroform extract of Launaea procumbens against CCl4-induced injuries in rats. PubMed: Beneficial Effects of Ocimum gratissimum Aqueous Extract on Rats with CCl(4)-Induced Acute Liver Injury. PubMed: Food-related compounds that modulate expression of inducible nitric oxide synthase may act as its inhibitors. PubMed: Edible oils for liver protection: hepatoprotective potentiality of Moringa oleifera seed oil against chemical-induced hepatitis in rats. PubMed: Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line. PubMed: Mulberry water extracts (MWEs) ameliorated carbon tetrachloride-induced liver damages in rat. PubMed: Novel antiosteoclastogenic activity of phloretin antagonizing RANKL-induced osteoclast differentiation of murine macrophages. PubMed: Autophagy, polyphenols and healthy ageing. PubMed: Osteogenic activity of silymarin through enhancement of alkaline phosphatase and osteocalcin in osteoblasts and tibia-fractured mice. PubMed: A profile of bioactive compounds of Rumex vesicarius L. PubMed: Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis. PubMed: DPPH free radical scavenging activity and phenotypic difference in hepatoprotective plant (Silybum marianum L.). PubMed: Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. PubMed: In vitro determination of anticryptosporidial activity of phytogenic extracts and compounds. PubMed: Hepatoprotection of Gentiana scabra extract and polyphenols in liver of carbon tetrachloride-intoxicated mice. PubMed: [Determination of active components in silymarin by UPLC-ESIMS]. PubMed: Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. PubMed: Osteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts. PubMed: Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat. PubMed: Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis in mice. PubMed: Toxicology and carcinogenesis studies of milk thistle extract (CAS No. 84604-20-6) in F344/N rats and B6C3F1 mice (Feed Studies). PubMed: Effects of long-term silymarin oral supplementation on the blood biochemical profile of rainbow trout (Oncorhynchus mykiss). PubMed: In vitro and in vivo antioxidant activity of Symplocos cochinchinensis S. Moore leaves containing phenolic compounds. PubMed: Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol. PubMed: Oral administration of Trapa taiwanensis Nakai fruit skin extracts conferring hepatoprotection from CCl4-caused injury. PubMed: Highly sensitive detection of silybin based on adsorptive stripping analysis at single-sided heated screen-printed carbon electrodes modified with multi-walled carbon nanotubes with direct current heating. PubMed: Gentiana manshurica Kitagawa reverses acute alcohol-induced liver steatosis through blocking sterol regulatory element-binding protein-1 maturation. PubMed: Hepatoprotection by freshwater clam extract against CCl4-induced hepatic damage in rats. PubMed: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. PubMed: Rapid separation and characterization of active flavonolignans of Silybum marianum by ultra-performance liquid chromatography coupled with electrospray tandem mass spectrometry. PubMed: Silymarin: a novel antioxidant with antiglycation and antiinflammatory properties in vitro and in vivo. PubMed: Effects of plant-derived polyphenols on TNF-alpha and nitric oxide production induced by advanced glycation endproducts. PubMed: Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: evidence from gene expression profiles. PubMed: Influence of chrysin on hepatic marker enzymes and lipid profile against D-galactosamine-induced hepatotoxicity rats. PubMed: Protective effects of silica hydride against carbon tetrachloride-induced hepatotoxicity in mice. PubMed: Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage. PubMed: Establishment of a methodology for investigating protectants against ethanol-induced hepatotoxicity. PubMed: Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. PubMed: Hepatoprotection of chlorella against carbon tetrachloride-induced oxidative damage in rats. PubMed: Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats. PubMed: Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain. PubMed: Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice. PubMed: Improvement for high fat diet-induced hepatic injuries and oxidative stress by flavonoid-enriched extract from Nelumbo nucifera leaf. PubMed: Hepatoprotective activity of polyherbal formulation (Normeta) in oxidative stress induced by alcohol, polyunsaturated fatty acids and iron in rats. PubMed: Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. PubMed: Mushroom poisoning in children: clinical presentation and outcome. PubMed: PEGylated lactoferrin enhanced its hepatoprotective effects on acute liver injury induced by carbon tetrachloride in rats. PubMed: Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats. PubMed: Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells. PubMed: Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 Cells. PubMed: Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats. PubMed: [The comparative analysis of two methods of an estimation a butter's quality at its long storage and influence of a thistle spotty extracts on a period of storage]. PubMed: Glycyrrhizic acid modulates t-BHP induced apoptosis in primary rat hepatocytes. PubMed: In vitro antioxidant activity of silymarin. PubMed: Effect of silymarin on metabolic factors of food-restricted over conditioned Wistar rats. PubMed: Sodium borohydride/chloranil-based assay for quantifying total flavonoids. PubMed: Protective effects of Dunaliella salina--a carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice. PubMed: Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats. PubMed: Multiple treatment of propolis extract ameliorates carbon tetrachloride induced liver injury in rats. PubMed: Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level. PubMed: Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats. PubMed: Milk thistle extracts inhibit the oxidation of low-density lipoprotein (LDL) and subsequent scavenger receptor-dependent monocyte adhesion. PubMed: Separation and determination of flavonoids using microemulsion EKC with electrochemical detection. PubMed: Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages. PubMed: Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment. PubMed: Cell cycle control as a basis for cancer chemoprevention through dietary agents. PubMed: Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells. PubMed: Silymarin as an adjunct to glibenclamide therapy improves long-term and postprandial glycemic control and body mass index in type 2 diabetes. PubMed: The potential of milk thistle (Silybum marianum L.), an Israeli native, as a source of edible sprouts rich in antioxidants. PubMed: Therapeutic value of orally administered silibinin in renal cell carcinoma: manipulation of insulin-like growth factor binding protein-3 levels. PubMed: Effects of Picrorrhiza rhizoma water extracts on the subacute liver damages induced by carbon tetrachloride. PubMed: Antioxidant and protective effect of an oleanolic acid-enriched extract of A. deliciosa root on carbon tetrachloride induced rat liver injury. PubMed: Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites. PubMed: Hepatoprotective and antioxidative effects of total phenolics from Laggera pterodonta on chemical-induced injury in primary cultured neonatal rat hepatocytes. PubMed: Effects of the plant flavonoids silymarin and quercetin on arsenite-induced oxidative stress in CHO-K1 cells. PubMed: Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells. PubMed: Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. PubMed: [The use of flavolignans of "Silybum marianum (L.) Gaertn." to create a new fat product--fortified butter]. PubMed: Molecular targets of dietary agents for prevention and therapy of cancer. PubMed: A silychristin isomer and variation of flavonolignan levels in milk thistle (Silybum marianum) fruits. PubMed: The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats. PubMed: Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5). PubMed: Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats. PubMed: Dietary antioxidant compounds and liver health. PubMed: Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks. PubMed: [Hepatoprotective effects of silymarin in androgenic-anabolic steroid-induced liver damage]. PubMed: Effects of silymarin, a natural hepatoprotector, in periparturient dairy cows. PubMed: Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport. PubMed: Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. PubMed: Silymarin, a possible hepatoprotector in dairy cows: biochemical and histological observations. PubMed: Antioxidant action of Moringa oleifera Lam. (drumstick) against antitubercular drugs induced lipid peroxidation in rats. PubMed: Influence of Piper betle on hepatic marker enzymes and tissue antioxidant status in ethanol-treated Wistar rats. PubMed: The evaluation of reno- and hepatoprotective effects of huai-shan-yao (Rhizome Dioscoreae). PubMed: Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. PubMed: Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels. PubMed: Hepatoprotective and anti-Helicobacter pylori activities of constituents from Brazilian propolis. PubMed: Allied studies on the effect of Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis. PubMed: Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells. PubMed: Interference by carbohydrate substrates, flavonoids, and monosaccharide derivatives on bacterial beta-D-glucuronidase assays. PubMed: [Biologically active additive from milk thistle in the solution of public health problems]. PubMed: In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds. PubMed: Flavonoids modulate comet assay responses to food mutagens in human lymphocytes and sperm. PubMed: Protective effect of flavonoids and tocopherol in high altitude hypoxia in the rat: comparison with ascorbic acid. PubMed: Free radical scavenging and antioxidative properties of 'silibin' complexes on microsomal lipid peroxidation. PubMed: Modulating effects of flavonoids on food mutagens in human blood and sperm samples in the comet assay. PubMed: Effect of silymarin on different acute inflammation models and on leukocyte migration. PubMed: Amanita poisoning during the second trimester of pregnancy. A case report and a review of the literature. PubMed: Research note: efficacy of various flavonoids and simple phenolics in prevention of nutritional myopathy in the chick.