cinchonan-9-ol, 6'-methoxy-, (8a,9R)-

CAS: 130-95-0 C20 H24 N2 O2 MW: 324.42368000 odorless bitter

Identification

Namequinine
CAS Number130-95-0
EINECS205-003-2
FDA UNIIA7V27PHC7A
Molecular FormulaC20 H24 N2 O2
Molecular Weight324.42368000
MDL NumberMFCD00198096
Nikkaji NumberJ654.524F
Beilstein91867
XlogP32.90 (est)

Regulatory

Physical Properties

Appearance pale yellow to brown needles (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 177.00 °C. @ 760.00 mm Hg
Boiling Point 495.00 to 496.00 °C. @ 760.00 mm Hg (est)
Flash Point 489.00 °F. TCC ( 253.70 °C. ) (est)
logP (o/w) 3.440
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesdenaturants

Organoleptic Properties

Taste Description bitter

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-cat LDLo 100 mg/kg
Dermal Toxicitysubcutaneous-cat LDLo 100 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA', 'BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA\nBLOOD: OTHER CHANGES\nCARDIAC: OTHER CHANGES', 'CARDIAC: OTHER CHANGES\nBLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA\nBLOOD: OTHER CHANGES']

Safety in Use

Categorycosmetic agents
Recommendation for quinine usage levels up tonot for fragrance use.
Recommendation for quinine flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Potential Uses

None Found

Natural Occurrence

cinchona bark PMC red bark PMC

Synonyms

chinin cinchonan-9-ol, 6'-methoxy-, (3a,8a,9R)- cinchonan-9-ol, 6'-methoxy-, (8a,9R)- (R)-[(2S,4S,5R)-5- ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol (R)-(6- methoxy-4-chinolinyl)[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol (R)-(6- methoxy-4-quinolinyl)[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol (3a,8a,9R)-6'- methoxycinchonan-9-ol (8a,9R)-6'- methoxycinchonan-9-ol 6'- methoxycinchonan-9-ol (8S,9R)- quinine (R)-(-)- quinine Info: Quinine PubMed: [Kansei biosensors to reproduce gustatory and olfactory senses]. PubMed: Role of NMDA, opioid and dopamine D1 and D2 receptor signaling in the acquisition of a quinine-conditioned flavor avoidance in rats. PubMed: Taste loss in hospitalized multimorbid elderly subjects. PubMed: Genetic analysis of chemosensory traits in human twins. PubMed: Somatosensory factors in taste perception: effects of active tasting and solution temperature. PubMed: [Functional MRI investigation of brain activity triggered by taste stimulation]. PubMed: Rational development of taste masked oral liquids guided by an electronic tongue. PubMed: Evidence for an integrated oral sensory module in the human anterior ventral insula. PubMed: The role of transient receptor potential vanilloid-1 on neural responses to acids by the chorda tympani, glossopharyngeal and superior laryngeal nerves in mice. PubMed: Structural analogues of homoeriodictyol as flavor modifiers. Part III: short chain gingerdione derivatives. PubMed: Potentiation of taste and extract stimuli in conditioned flavor preference learning. PubMed: New bitter-masking compounds: hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol. PubMed: Hunger alters the expression of acquired hedonic but not sensory qualities of food-paired odors in humans. PubMed: Olfactory influences on appetite and satiety in humans. PubMed: Olfactory influences on appetite and satiety in humans. PubMed: Taste masking analysis in pharmaceutical formulation development using an electronic tongue. PubMed: Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification. PubMed: 'Thermal taste' predicts higher responsiveness to chemical taste and flavor. PubMed: Two procedures establishing preference for oral cocaine and lidocaine solutions which do not use an associative history with a reinforcer. PubMed: Interaction of gustatory and lingual somatosensory perceptions at the cortical level in the human: a functional magnetic resonance imaging study. PubMed: An opioid receptor antagonist, naltrexone, does not alter taste and smell responses in humans. PubMed: The representation of umami taste in the taste cortex. PubMed: Glutamate and the flavor of foods. PubMed: Factors affecting the perception of naturalness and flavor strength in citrus drinks. PubMed: The neurophysiology of taste and olfaction in primates, and umami flavor. PubMed: Flavor avoidance learning and its implications in reducing strychnine baiting hazards to nontarget animals. PubMed: Glucose- and fructose-conditioned flavor preferences in rats: taste versus postingestive conditioning. PubMed: Oral caffeine consumption by rats: the role of flavor history, concentration, concurrent food, and an adenosine agonist. PubMed: Preference of Old World monkeys for amino acids and other gustatory stimuli: the influence of monosodium glutamate. PubMed: Influence of the sense of taste on broiler chick feed consumption. PubMed: Conditioned flavor preferences based on delayed caloric consequences. PubMed: Norepinephrine-facilitated eating: reduction in saccharin preference and conditioned flavor preferences with increase in quinine aversion. PubMed: Rats learn to like the taste of morphine. PubMed: Use of taste repellants and emetics to prevent accidental poisoning of dogs. PubMed: Developmental flavor experience affects utilization of odor, not taste in toxiphobic conditioning. PubMed: Flavor enhances the antidipsogenic effect of naloxone.