hydroxocobalamin
alpha-(5,6-dimethylbenzimidazolyl)hydroxocobamide
Identification
| Name | hydroxocobalamin |
| IUPAC | cobalt(2+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl][(2S)-1-[3-[(2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18- |
| CAS Number | 13422-51-0 |
| EINECS | 236-533-2 |
| FDA UNII | Q40X8H422O |
| Molecular Formula | C62 H90 Co N13 O15 P |
| Molecular Weight | 1347.38525700 |
Regulatory
Physical Properties
| Appearance | dark red crystalline powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 200.00 °C. @ 760.00 mm Hg |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | -2.812 (est) |
| Soluble in | water, 1.336e-007 mg/L @ 25 °C (est) |
Organoleptic Properties
| Odor Description | odorless |
Safety Information
| Oral/Parenteral Toxicity | intravenous-mouse LD50 > 50 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | special dietary and nutritional additives |
| Recommendation for hydroxocobalamin usage levels up to | not for fragrance use. |
| Recommendation for hydroxocobalamin flavor usage levels up to | not for flavor use. |
American International Chemical, Inc.
Consistent sources
North American supplier for globally sourced ingredients.
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Potential Uses
Natural Occurrence
Synonyms
alpharedisol
axion
ciplamin H
cobalamin, hydroxo-
cobalex
codroxomin
depogamma
a-(5,6-
dimethylbenzimidazolyl)hydroxocobamide
alpha-(5,6-
dimethylbenzimidazolyl)hydroxocobamide
hydrobamine
hydrocobalamin
hydrogrisevit
hydroxocobalamine
hydroxocobemine
hydroxy vitamin B12
hydroxycobalamin
hydroxycobalamine
idrogrisevit
vitadurin
vitamin B(sub 12a)
vitamin B12a
PubMed:
Intravenous Cobinamide Versus Hydroxocobalamin for Acute Treatment of Severe Cyanide Poisoning in a Swine (Sus scrofa) Model.
PubMed:
[Clinical, biological and therapeutic profile of anemia by vitamin B12 deficiency in the department of hematology of Marrakech (Morocco)].
PubMed:
Blood leak alarm interference by hydoxocobalamin is hemodialysis machine dependent.
PubMed:
Antidotes for acute cyanide poisoning.
PubMed:
Empiric management of cyanide toxicity associated with smoke inhalation.
PubMed:
Smoke inhalation injury in a pregnant patient: a literature review of the evidence and current best practices in the setting of a classic case.
PubMed:
Loss of vitamin B(12) in fish (round herring) meats during various cooking treatments.
PubMed:
Cob(I)alamin reacts with sucralose to afford an alkylcobalamin: relevance to in vivo cobalamin and sucralose interaction.
PubMed:
Determination of cobalamin in nutritive supplements and chlorella foods by capillary electrophoresis-inductively coupled plasma mass spectrometry.
PubMed:
Dietary folate deficiency and bilateral retinal haemorrhages.
PubMed:
Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency.
PubMed:
Determination of vitamin B12 using the enzyme glycerol dehydrase.
PubMed:
Effect of homocysteine reduction by B-vitamin supplementation on markers of clotting activation.
PubMed:
Picomolar quantitation of free sulfite in foods by means of [57Co]hydroxocobalamin and radiometric chromatography of [57Co]sulfitocobalamin. Method, applications and significance of coexisting sulfides.
PubMed:
Nitritocobalamin and nitrosocobalamin may be confused with sulfitocobalamin using cation-exchange chromatography.
PubMed:
Vitamin B12 metabolism in a photosynthesizing green alga, Chlamydomonas reinhardtii.
PubMed:
Occurrence and tissue distribution of both NADH- and NADPH-linked aquacobalamin reductases in some vertebrates.
PubMed:
Significance of isomerization in hydroxocobalamin.
PubMed:
Measurement of vitamin B12 in the livers and sera of sheep and cattle and an investigation of factors influencing serum vitamin B12 levels in sheep.
PubMed:
Vitamin B12 assimilation from chicken meat.
PubMed:
Conversion of hydroxo(aquo) cobalamin to sulfitocobalamin in the absence of light: a reaction of importance in the identification of the forms of vitamin B12, with possible clinical significance.
PubMed:
The forms of vitamin B12 in foods.