copper orotate

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bis(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylato-N3,O4)copper

CAS: 61573-60-2 C10 H6 Cu N4 O8 MW: 373.72542000
All Ingredients Aromatic Ingredients CAS Numbers EINECS Numbers Food Additives - Direct

Identification

Namecopper orotate
IUPACcopper 2,4-dioxo-1H-pyrimidine-6-carboxylate
CAS Number61573-60-2
EINECS262-855-8
FDA UNIID0BDL7GZGO
Molecular FormulaC10 H6 Cu N4 O8
Molecular Weight373.72542000

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in water, 12.48 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynutrient supplements, EFSA concludes: use is of safety concern.
Recommendation for copper orotate usage levels up tonot for fragrance use.
Recommendation for copper orotate flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

copper 2,4-dioxo-1H-pyrimidine-6-carboxylate bis(1,2,3,6- tetrahydro-2,6-dioxo-4-pyrimidinecarboxylato-N3,O4)copper PubMed: Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial. PubMed: Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial. PubMed: The orotate transporter encoded by oroP from Lactococcus lactis is required for orotate utilization and has utility as a food-grade selectable marker. PubMed: Diamine oxidase, a plasma biomarker in rats to GI tract toxicity of oral fluorouracil anti-cancer drugs. Google Patents: Copper orotate PubMed: Bis(triphenylphosphine)copper(I) Complexes of Orotate and L-Dihydroorotate. PubMed: Role of magnesium cations in the yeast orotate phosphoribosyltransferase catalyzed reaction. Mechanism of the inhibition by Cu++ and Ni++ ions.