orthosilicic acid

CAS: 10193-36-9 H4 O4 Si MW: 96.11398000

Identification

Nameorthosilicic acid
IUPACsilicic acid (H4SiO4)
CAS Number10193-36-9
EINECS233-477-0
FDA UNII623B93YABH
Molecular FormulaH4 O4 Si
Molecular Weight96.11398000
MDL NumberMFCD01941556
Nikkaji NumberJ148.210F

Regulatory

Physical Properties

Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) -0.304 (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral Toxicityintraperitoneal-guinea pig LDLo 120 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryfood additive: EFSA: as choline-stabilised orthosilicic acid only
Recommendation for orthosilicic acid usage levels up tonot for fragrance use.
Recommendation for orthosilicic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

silicic acid (H4SiO4) tetrahydroxysilane PubMed: Determination of plant silicon content with near infrared reflectance spectroscopy. PubMed: Silicon: The evolution of its use in biomaterials. PubMed: There are not enough data to conclude that Monomethylsilanetriol is safe. PubMed: Silicon: the health benefits of a metalloid. PubMed: Silicon balance in human volunteers; a pilot study to establish the variance in silicon excretion versus intake. PubMed: Aquaglyceroporins: generalized metalloid channels. PubMed: The performance of an orthosilicic acid-releasing silica gel fiber fleece in wound healing. PubMed: The silicon supplement 'Monomethylsilanetriol' is safe and increases the body pool of silicon in healthy Pre-menopausal women. PubMed: Silicon absorption and excretion is independent of age and sex in adults. PubMed: Instant food products as a source of silicon. PubMed: Taste and mouthfeel assessment of porous and non-porous silicon microparticles. PubMed: Modification of alginate degradation properties using orthosilicic acid. PubMed: Zwitterionic and anionic multinuclear pentacoordinate silicon(IV) complexes with bridging (R,R)-tartrato(4-) ligands and SiO5 skeletons: synthesis and reactivity in aqueous solution. PubMed: A theoretical kinetic model of the temperature and pH dependent dimerization of orthosilicic acid in aqueous solution. PubMed: Interactions of amines with silicon species in undersaturated solutions leads to dissolution and/or precipitation of silica. PubMed: Reactions at interfaces: oxygenation of n-butyl ligands anchored on silica surfaces with methyl(trifluoromethyl)dioxirane. PubMed: A solution study of silica condensation and speciation with relevance to in vitro investigations of biosilicification. PubMed: Efficient and stable enzyme immobilization in a block copolypeptide vesicle-templated biomimetic silica support. PubMed: [Progress in silicatein from sponges]. PubMed: The comparative absorption of silicon from different foods and food supplements. PubMed: Moderate ingestion of alcohol is associated with acute ethanol-induced suppression of circulating CTX in a PTH-independent fashion. PubMed: An overview of silica in biology: its chemistry and recent technological advances. PubMed: Divergent effects of orthosilicic acid and dimethylsilanediol on cell survival and adhesion in human osteoblast-like cells. PubMed: Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. PubMed: Avoidance of aluminum toxicity in freshwater snails involves intracellular silicon-aluminum biointeraction. PubMed: Mineral balance in horses fed two supplemental silicon sources. PubMed: Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair. PubMed: Vitamins and minerals: their role in nail health and disease. PubMed: The chemistry of silica and its potential health benefits. PubMed: Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid. PubMed: Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin. PubMed: Role of exogenous and endogenous silicon in ameliorating behavioural responses to aluminium in a freshwater snail. PubMed: The silicon content of beer and its bioavailability in healthy volunteers. PubMed: Emission, fate and effects of soluble silicates (waterglass) in the aquatic environment. PubMed: Silica deposition by a strongly cationic proline-rich protein from systemically resistant cucumber plants. PubMed: Effect of orthosilicic acid on the accumulation of trace metals by the pond snail Lymnaea stagnalis. PubMed: Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. PubMed: Associations of squaric acid and its anions as multiform building blocks of hydrogen-bonded molecular crystals. PubMed: Near-infrared spectroscopic study of [AlO4Al12(OH)23(H2O)12]7+-O-Si(OH)3 nitrate crystals formed by forced hydrolysis of Al3+ in the presence of TEOS. PubMed: Silica deposition in Demosponges: spiculogenesis in Crambe crambe. PubMed: Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. PubMed: Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage. PubMed: [Biological and pharmacological properties of orthosilicic acid and its derivatives and their effect on the body]. PubMed: [Determination of triethoxysilane and the ethyl ether of orthosilicic acid (tetraethoxysilane) in the air]. PubMed: [Determination of small quantities ethyl ether of orthosilicic acid (ethylsilicate) in the air].