benfotiamine

allithiamine S-[(Z)-2-[(4- amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate S-(2-(N-((4- amino-2-methylpyrimidin-5-yl)methyl)formamido)-5-(phosphonooxy)pent-2-en-3-yl)benzothioate S-[(2Z)-2-{[(4- amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-5-(phosphonooxy)pent-2-en-3-yl] benzenecarbothioate (3Z)-4-{N-[(4- amino-2-methylpyrimidin-5-yl)methyl]carbonylamino}-3-(phenylcarbonylthio)pent-3-enyl dihydrogen phosphate benphothiamine benzenecarbothioic acid, S-[(1Z)-2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester benzoic acid, thio-, S-ester with N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide dihydrogen phosphate (ester) benzoylthiamine monophosphate S- benzoylthiamine monophosphate benzoylthiamine O-monophosphate S- benzoylthiamine O-monophosphate benzoylthiaminmonophosphate bietamine biotamin BTMP 6-(2- methyl-6-amino-5-pyrimidinyl)-5-aza-5-formyl-4-methyl-3-benzoylthio-3-hexenyl phosphate neurostop nitanevril tabiomyl thiamine monophosphate benzoyl vitanevril PubMed: Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride. PubMed: A novel spectral resolution and simultaneous determination of multicomponent mixture of Vitamins B1, B6, B12, Benfotiamine and Diclofenac in tablets and capsules by derivative and MCR-ALS. PubMed: The effect of benfotiamine on mu-opioid receptor mediated antinociception in experimental diabetes. PubMed: Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells. PubMed: Effect of benfotiamine in podocyte damage induced by peritoneal dialysis fluid. PubMed: Paraptosis cell death induction by the thiamine analog benfotiamine in leukemia cells. PubMed: Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia. PubMed: A randomized, double-blind, crossover, placebo-controlled trial of 6 weeks benfotiamine treatment on postprandial vascular function and variables of autonomic nerve function in Type 2 diabetes. PubMed: Benfotiamine enhances antioxidant defenses and protects against cisplatin-induced DNA damage in nephrotoxic rats. PubMed: Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence. PubMed: Variability of skin autofluorescence measurement over 6 and 12 weeks and the influence of benfotiamine treatment. PubMed: Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration. PubMed: Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose. PubMed: Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity. PubMed: Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. PubMed: Annexin V imaging detects diabetes-accelerated apoptosis and monitors the efficacy of benfotiamine treatment in ischemic limbs of mice. PubMed: Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations. PubMed: Pharmacokinetics of the transdermal delivery of benfotiamine. PubMed: The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial. PubMed: Antiglycation activity of thiamin-HCl and benfotiamine in diabetic condition. PubMed: Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy. PubMed: [The effect of long-chain polyunsaturated higher ω-3 fatty acids, benfotiamine and α-lipoic acid on the lipid metabolism in patients with diabetes mellitus type 2 and cardiovascular autonomic neuropathy]. PubMed: Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis. PubMed: Benfotiamine counteracts smoking-induced vascular dysfunction in healthy smokers. PubMed: Solubility enhancement of benfotiamine, a lipid derivative of thiamine by solid dispersion technique. PubMed: Preventive effects of benfotiamine in chronic diabetic complications. PubMed: Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PubMed: Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. PubMed: The multifaceted therapeutic potential of benfotiamine. PubMed: The defensive effect of benfotiamine in sodium arsenite-induced experimental vascular endothelial dysfunction. PubMed: A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy. PubMed: Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes. PubMed: PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine. PubMed: Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. PubMed: Comment on: Fraser et al. The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial. Diabetes Care 2012;35:1095-1097. PubMed: Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response. PubMed: Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. PubMed: Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment. PubMed: Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes. PubMed: Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway. PubMed: Pharmacologic Approaches Against Advanced Glycation End Products (AGEs) in Diabetic Cardiovascular Disease. PubMed: Detection of transketolase in bone marrow-derived insulin-producing cells: benfotiamine enhances insulin synthesis and glucose metabolism. PubMed: Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. PubMed: Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. PubMed: Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis. PubMed: Antinociceptive interaction between benfotiamine and resveratrol in capsaicin-induced licking. PubMed: Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat. PubMed: Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. PubMed: Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study). PubMed: Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. PubMed: Synergistic antiallodynic interaction between gabapentin or carbamazepine and either benfotiamine or cyanocobalamin in neuropathic rats. PubMed: Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. PubMed: Thiamine and benfotiamine prevent increased apoptosis in endothelial cells and pericytes cultured in high glucose. PubMed: Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. PubMed: Pharmacokinetics of thiamine derivatives especially of benfotiamine. PubMed: High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus. PubMed: Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. PubMed: Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients. PubMed: Benfotiamine relieves inflammatory and neuropathic pain in rats. PubMed: Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. PubMed: Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study (BAP I Study). PubMed: Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. PubMed: Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha. PubMed: Comparative autoradiographic investigations on the tissue distribution of benfotiamine versus thiamine in mice. PubMed: Benfotiamine attenuates nicotine and uric acid-induced vascular endothelial dysfunction in the rat. PubMed: Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. PubMed: Inhibition of macrophage oxidative stress prevents the reduction of ABCA-1 transporter induced by advanced glycated albumin. PubMed: Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes. PubMed: Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications. PubMed: Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. PubMed: Current therapeutic interventions in the glycation pathway: evidence from clinical studies. PubMed: Efficacy and tolerability of advanced glycation end-products inhibitor in osteoarthritis: a randomized, double-blind, placebo-controlled study. PubMed: Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. PubMed: Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling. PubMed: A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. PubMed: New oral dosage form for elderly patients. II. Release behavior of benfotiamine from silk fibroin gel. PubMed: [The immunometaboic effects of benfotiamine and riboxine on hemolytic anemia]. PubMed: Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes. PubMed: [Oral benfotiamine therapy. Thus you protect the nerves of diabetic patients]. PubMed: [Chronic alcohol abuse. Benfotiamine in alcohol damage is a must]. PubMed: Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate. PubMed: Adiponectin decreases postprandially following a heat-processed meal in individuals with type 2 diabetes: an effect prevented by benfotiamine and cooking method. PubMed: Benfotiamine. Monograph. PubMed: Vitamins and their derivatives in the prevention and treatment of metabolic syndrome diseases (diabetes). PubMed: Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis. PubMed: [The effect of benfothiamine in the therapy of diabetic polyneuropathy]. PubMed: High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine. PubMed: Detrimental effects of acute hyperglycaemia on the rat heart. PubMed: [Pathomechanism of diabetic neuropathy: background of the pathogenesis-oriented therapy]. PubMed: [Clinical use of benphothiamine]. PubMed: [A comparative study of blood thiamine levels after injection of thiamine chlorhydrate and per os administration of Benfotiamine]. PubMed: Burning through the pain: treatments for diabetic neuropathy. PubMed: Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation? PubMed: Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine. PubMed: Effects of high glucose and thiamine on the balance between matrix metalloproteinases and their tissue inhibitors in vascular cells. PubMed: High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats. PubMed: Vitamin B and its derivatives for diabetic kidney disease. PubMed: Treatment of painful diabetic neuropathy. PubMed: Diabetic neuropathy and oxidative stress: therapeutic perspectives. PubMed: The detrimental effects of acute hyperglycemia on myocardial glucose uptake. PubMed: Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK. PubMed: Inhibition of AGEs formation by natural products. PubMed: Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage. PubMed: High-throughput screening of small molecules identifies hepcidin antagonists. PubMed: Current options and perspectives in the treatment of diabetic neuropathy. PubMed: [The immunomodulating action of energizing preparations under physical loading]. PubMed: A case of rheumatoid arthritis presenting with postherpetic neuralgia and abdominal-wall pseudohernia. PubMed: Glucose effects on the peritoneum: what can we learn from rodent models? PubMed: Lipid glycation and protein glycation in diabetes and atherosclerosis. PubMed: [Neuropathy pain: tactic of treatment]. PubMed: [The role of neurotropic therapy in the treatment of acute sensorineural impairment of hearing following a viral infection]. PubMed: [A relationship between analgesic and neurotropic effects by the example of milgamma]. PubMed: [The optimization of the treatment of the vertebrogenic pain syndrome: neurotrophic treatment potentiates the effect of nonsteroidal anti-inflammatory drugs]. PubMed: [The importance of the pharmaceutical form and the routes of administration of B-group vitamins for the efficacious treatment of neurosensorial hearing loss]. PubMed: [Prophylactic and therapeutic application of thiamine (vitamin B1)--a new point of view]. PubMed: [Medicamentous therapy of alcoholic polyneuropathy. Randomized double-blind study comparing 2 vitamin B preparations and a nucleotide preparation]. PubMed: Diabetic neuropathy: new strategies for treatment. PubMed: Vitamin B1 blocks damage caused by hyperglycemia. PubMed: Metabolic correction in the management of diabetic peripheral neuropathy: improving clinical results beyond symptom control. PubMed: [Prevention of complications in diabetes mellitus. Interdisciplinary collaboration to control sequelae]. PubMed: Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy. PubMed: Could thiamine pyrophosphate be a regulator of the nitric oxide synthesis in the endothelial cell of diabetic patients? PubMed: Drugs for the treatment of diabetes complications. Zycose: a new player in the field? PubMed: [Cochleovestibular disorders: approaches to diagnostics and treatment]. PubMed: [Sensorineural hearing loss: New prospects for therapy]. PubMed: Oxidative stress in diabetic kidney disease. PubMed: Skin autofluorescence as a measure of advanced glycation endproduct deposition: a novel risk marker in chronic kidney disease. PubMed: [Diabetic neuropathies and angiopathies. Compensating for thiamine deficiency]. PubMed: High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats. PubMed: [Pharmacologic therapy in peripheral diabetic polyneuropathy]. PubMed: Diabetes mellitus induces bone marrow microangiopathy. PubMed: [The myocardial contractile function and central hemodynamics of patients with insulin-dependent diabetes mellitus during treatment]. PubMed: [Treatment of neuropathies]. PubMed: Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy. PubMed: Effectiveness and retention of thiamine and its analogs administered to steelhead and landlocked Atlantic salmon. PubMed: New approaches for the treatment of genomic damage in end-stage renal disease. PubMed: Vitamin B for treating peripheral neuropathy. PubMed: The potential role of thiamine (vitamin B1) in diabetic complications. PubMed: Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes. PubMed: Schlafen 3, a novel gene, regulates colonic mucosal growth during aging. PubMed: [Vitamin B complex (milgamma) in the treatment of vertebrogenic lumbosacral radiculopathy]. PubMed: [Correction of metabolic disturbances in patients with stable effort angina and metabolic syndrome]. PubMed: [Structural and functional changes of arterial vessels in patients with ischemic heart disease and metabolic syndrome]. PubMed: [Neurometabolic therapy of diabetic neuropathy]. PubMed: [Development of therapeutic agents for diabetic neuropathies]. PubMed: [Progress on the drug therapy for diabetic microangiopathies: AGE inhibitors]. PubMed: [Diabetes mellitus. Retinal lesions should not exist!]. PubMed: Bioavailability of water- and lipid-soluble thiamin compounds in broiler chickens. PubMed: Effect of high-dosed thiamine hydrochloride and S-benzoyl-thiamine-O-monophosphate on thiamine-status after chronic ethanol administration. PubMed: [Diabetic polyneuropathy treatment by milgamma-100 preparation]. PubMed: A 6-month-old girl with cardiomyopathy who nearly died. PubMed: Therapeutic efficacy of "Milgamma" in patients with painful diabetic neuropathy. PubMed: [The effectiveness of the neurotropic agents: benfotiamin combinations]. PubMed: [Physical work capacity in diabetes mellitus under treatment]. PubMed: Crystal structures of the thi-box riboswitch bound to thiamine pyrophosphate analogs reveal adaptive RNA-small molecule recognition. PubMed: The role of AGEs and AGE inhibitors in diabetic cardiovascular disease. PubMed: Advances in biochemical mechanisms of diabetic retinopathy. PubMed: An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain. PubMed: Evaluating thiamine deficiency in patients with diabetes. PubMed: [Role of mitochondrial dysfunction in pathogenesis of diabetic microangiopathy]. PubMed: [Milgamma in the treatment of chronic neurosensory hypoacusis]. PubMed: [Treatment of neuropathies]. PubMed: [Bendotiamine efficacy in alcoholic polyneuropathy therapy]. PubMed: [Diabetic neuropathy]. PubMed: Biokinetic parameters and metabolism of S-benzoylthiamine-O-monophosphate. PubMed: Alteration of thiamine pharmacokinetics by end-stage renal disease (ESRD). PubMed: Comparative bioavailability of various thiamine derivatives after oral administration. PubMed: Excretion of intracorporeal cadmium with S-benzoylthiamin monophosphate. PubMed: [Characteristic features of 35S-benzoylthiamine monophosphate in albino mice]. PubMed: Peripheral neuropathy: pathogenic mechanisms and alternative therapies. PubMed: Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. PubMed: Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats.