bis(maltolato)oxovanadium(IV)

BMOV(IV) 2- methyl-4-oxopyran-3-olate; oxovanadium(2+) vanadium, bis(3-hydroxy-2-methyl-4H-pyran-4-onato-O3,O4)oxo-, (SP-5-31)- PubMed: Oxovanadium-based inhibitors can drive redox-sensitive cytotoxicity in neuroblastoma cells and synergise strongly with buthionine sulfoximine. PubMed: Exposure to bis(maltolato)oxovanadium(IV) increases levels of hepcidin mRNA and impairs the homeostasis of iron but not that of manganese. PubMed: Changes in iron metabolism and oxidative status in STZ-induced diabetic rats treated with bis(maltolato) oxovanadium (IV) as an antidiabetic agent. PubMed: Speciation studies of vanadium in human liver (HepG2) cells after in vitro exposure to bis(maltolato)oxovanadium(IV) using HPLC online with elemental and molecular mass spectrometry. PubMed: Aggravation by vanadium of magnesium deficiency in STZ-induced diabetic rats. PubMed: Bis(acetylacetonato)-oxovanadium(iv), bis(maltolato)-oxovanadium(iv) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt. PubMed: Changes in the antioxidant defence and in selenium concentration in tissues of vanadium exposed rats. PubMed: The anti-diabetic bis(maltolato)oxovanadium(IV) decreases lipid order while increasing insulin receptor localization in membrane microdomains. PubMed: Inhibition of protein tyrosine phosphatase improves angiogenesis via enhancing Ang-1/Tie-2 signaling in diabetes. PubMed: Vanadium compounds affect growth and morphology of human rhabdomyosarcoma cell line. PubMed: Biotransformation of BMOV in the presence of blood serum proteins. PubMed: Effect of bis(maltolato)oxovanadium (IV) (BMOV) on selenium nutritional status in diabetic streptozotocin rats. PubMed: Bioavailability, tissue distribution and hypoglycaemic effect of vanadium in magnesium-deficient rats. PubMed: Absorption, transport and insulin-mimetic properties of bis(maltolato)oxovanadium (IV) in streptozotocin-induced hyperglycemic rats by integrated mass spectrometric techniques. PubMed: Antidiabetic vanadium compound and membrane interfaces: interface-facilitated metal complex hydrolysis. PubMed: Vibrational spectra of bis(maltolato)oxovanadium(IV): a potent insulin mimetic agent. PubMed: Study of the antidiabetic capacity of the VO(dmpp)2 complex. PubMed: Antidiabetic Bis-Maltolato-OxoVanadium(IV): conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B. PubMed: Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes. PubMed: Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes to its glucoregulatory responses (review). PubMed: Vanadium treatment of type 2 diabetes: a view to the future. PubMed: Calorimetric studies of the interaction between the insulin-enhancing drug candidate bis(maltolato)oxovanadium(IV) (BMOV) and human serum apo-transferrin. PubMed: Effects of vanadium-containing compounds on membrane lipids and on microdomains used in receptor-mediated signaling. PubMed: Inhibition of protein tyrosine phosphatase 1B and alkaline phosphatase by bis(maltolato)oxovanadium (IV). PubMed: Sarcoplasmic reticulum calcium ATPase is inhibited by organic vanadium coordination compounds: pyridine-2,6-dicarboxylatodioxovanadium(V), BMOV, and an amavadine analogue. PubMed: The anti-diabetic effects and pharmacokinetic profiles of bis(maltolato)oxovanadium in non-diabetic and diabetic rats. PubMed: Vanadate, an inhibitor of stromelysin and collagenase expression, suppresses collagen induced arthritis. PubMed: Effect of bis (maltolato) oxovanadium (BMOV) in uric acid and sodium arsenite-induced vascular endothelial dysfunction in rats. PubMed: Molecular mechanism of bis(maltolato)oxovanadium(IV)-induced insulin signaling in 3T3-L1 and IM9 cells: impact of dexamethasone. PubMed: Involvement of insulin-like growth factor type 1 receptor and protein kinase Cdelta in bis(maltolato)oxovanadium(IV)-induced phosphorylation of protein kinase B in HepG2 cells. PubMed: Effect of bis(maltolato) oxovanadium on experimental vascular endothelial dysfunction. PubMed: Prevention of diabetes by inhibition of tyrosine phosphatases. PubMed: Differences in plasma homocysteine levels between Zucker fatty and Zucker diabetic fatty rats following 3 weeks oral administration of organic vanadium compounds. PubMed: Inhibition of protein tyrosin phosphatase improves vascular endothelial dysfunction. PubMed: The vanadyl (VO2+) chelate bis(acetylacetonato)oxovanadium(IV) potentiates tyrosine phosphorylation of the insulin receptor. PubMed: Structure and conformation of bis(acetylacetonato)oxovanadium(IV) and bis(maltolato)oxovanadium(IV) in solution determined by electron nuclear double resonance spectroscopy. PubMed: Royal Society of Chemistry--sixth international symposium on applied bioinorganic chemistry. PubMed: Coordination chemistry and insulin-enhancing behavior of vanadium complexes with maltol C6H6O3 structural isomers. PubMed: New insights into the interactions of serum proteins with bis(maltolato)oxovanadium(IV): transport and biotransformation of insulin-enhancing vanadium pharmaceuticals. PubMed: A nonspecific phosphotyrosine phosphatase inhibitor, bis(maltolato)oxovanadium(IV), improves glucose tolerance and prevents diabetes in Zucker diabetic fatty rats. PubMed: Synthesis, structural properties and insulin-enhancing potential of bis(quercetinato)oxovanadium(IV) conjugate. PubMed: Effects of three and eight weeks oral administration of bis(maltolato)oxovanadium(IV) on plasma homocysteine and cysteine levels in streptozotocin-induced diabetic rats. PubMed: The permeability and cytotoxicity of insulin-mimetic vanadium compounds. PubMed: [Hypoglycemic effects of bis(maltolato)oxovanadium administered by different routes upon diabetic rats]. PubMed: Comparison of anti-hyperglycemic effect amongst vanadium, molybdenum and other metal maltol complexes. PubMed: Streptozotocin-induced alterations in rat liver Golgi complexes are ameliorated by BMOV [Bis(maltolato)oxovanadium(IV)] activity. PubMed: The tyrosine phosphatase inhibitor bis(maltolato)oxovanadium attenuates myocardial reperfusion injury by opening ATP-sensitive potassium channels. PubMed: Tyrosine phosphatase inhibition augments collateral blood flow in a rat model of peripheral vascular disease. PubMed: Chronic glucose-lowering effects of rosiglitazone and bis(ethylmaltolato)oxovanadium(IV) in ZDF rats. PubMed: Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component. PubMed: The influence of BMOV [bis(maltolato)oxovanadium(IV)] on biochemical and morphological alterations characteristic for streptozotocin-diabetic rat liver Golgi complexes. PubMed: Preparation and characterization of vanadyl complexes with bidentate maltol-type ligands; in vivo comparisons of anti-diabetic therapeutic potential. PubMed: Mechanisms by which bis(maltolato)oxovanadium(IV) normalizes phosphoenolpyruvate carboxykinase and glucose-6-phosphatase expression in streptozotocin-diabetic rats in vivo. PubMed: The influence of a new vanadium compound, bis(2,2'-bipyridine)oxovanadium(IV) sulphate on liver golgi complexes from control and streptozotocin-diabetic rats. PubMed: Oral treatment with vanadium of Zucker fatty rats activates muscle glycogen synthesis and insulin-stimulated protein phosphatase-1 activity. PubMed: Vanadium increases GLUT4 in diabetic rat skeletal muscle. PubMed: Influence of chelation and oxidation state on vanadium bioavailability, and their effects on tissue concentrations of zinc, copper, and iron. PubMed: Bis(maltolato)oxovanadium(IV) inhibits the activity of PTP1B in Zucker rat skeletal muscle in vivo. PubMed: Effect of chronic treatment with Bis(maltolato)oxovanadium (IV) in rat model of non-insulin-dependent-diabetes. PubMed: Structural origins of the insulin-mimetic activity of bis(acetylacetonato)oxovanadium(IV). PubMed: In vivo effects of insulin and bis(maltolato)oxovanadium (IV) on PKB activity in the skeletal muscle and liver of diabetic rats. PubMed: In vivo effects of vanadium in diabetic rats are independent of changes in PI-3 kinase activity in skeletal muscle. PubMed: Insulin-enhancing vanadium(III) complexes. PubMed: Lack of in vivo effect of vanadium on GLUT4 translocation in white adipose tissue of streptozotocin-diabetic rats. PubMed: Effect of vanadium on insulin sensitivity and appetite. PubMed: Effect of vanadium(IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis(maltolato)oxovandium(IV). PubMed: In vivo effects of vanadium on GLUT4 translocation in cardiac tissue of STZ-diabetic rats. PubMed: Biochemical and morphological alterations in rat liver Golgi complexes after treatment with bis(maltolato)oxovanadium(IV) [BMOV] or maltol alone. PubMed: Selective phosphotyrosine phosphatase inhibition and increased ceramide formation is associated with B-cell death by apoptosis. PubMed: Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. PubMed: Effects of bis(maltolato) oxovanadium (IV) on protein serine kinases in skeletal muscle of streptozotocin-diabetic rats. PubMed: Tyrosine phosphorylation and morphological transformation induced by four vanadium compounds on MC3T3E1 cells. PubMed: Acute and chronic oral administration of bis(maltolato)oxovanadium(IV) in Zucker diabetic fatty (ZDF) rats. PubMed: Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats. PubMed: Influence of bis(maltolato)oxovanadium(IV) on activity of galactosyltransferase (GalT) and morphology of rat liver Golgi apparatus in control and streptozotocin diabetes. PubMed: Kinetic analysis and comparison of uptake, distribution, and excretion of 48V-labeled compounds in rats. PubMed: Glucose-lowering properties of vanadium compounds: comparison of coordination complexes with maltol or kojic acid as ligands. PubMed: Maltol complexes of vanadium (IV) and (V) regulate in vitro alkaline phosphatase activity and osteoblast-like cell growth. PubMed: Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. Redox independent activation of NF-kappaB. PubMed: Acute and chronic response to vanadium following two methods of streptozotocin-diabetes induction. PubMed: A polymer-based drug delivery system for the antineoplastic agent bis(maltolato)oxovanadium in mice. PubMed: Effects of bis(maltolato)oxovanadium(IV) are distinct from food restriction in STZ-diabetic rats. PubMed: Intracellular CD22 rapidly moves to the cell surface in a tyrosine kinase-dependent manner following antigen receptor stimulation. PubMed: Characterization of a CD43/leukosialin-mediated pathway for inducing apoptosis in human T-lymphoblastoid cells. PubMed: Characterization of the Potent Insulin Mimetic Agent Bis(maltolato)oxovanadium(IV) (BMOV) in Solution by EPR Spectroscopy. PubMed: Effects of low and high dose administration of bis(maltolato)oxovanadium(IV) on fa/fa Zucker rats. PubMed: Oxidation Kinetics of the Potent Insulin Mimetic Agent Bis(maltolato)oxovanadium(IV) (BMOV) in Water and in Methanol. PubMed: Vanadium chemistry and biochemistry of relevance for use of vanadium compounds as antidiabetic agents. PubMed: Skeletal muscle mitogen-activated protein kinases and ribosomal S6 kinases. Suppression in chronic diabetic rats and reversal by vanadium. PubMed: Lineage-specific induction of B cell apoptosis and altered signal transduction by the phosphotyrosine phosphatase inhibitor bis(maltolato)oxovanadium(IV). PubMed: Comparison of the glucose-lowering properties of vanadyl sulfate and bis(maltolato)oxovanadium(IV) following acute and chronic administration. PubMed: Bis(maltolato)oxovanadium(IV) attenuates hyperinsulinemia and hypertension in spontaneously hypertensive rats. PubMed: Improvement in cardiac dysfunction in streptozotocin-induced diabetic rats following chronic oral administration of bis(maltolato)oxovanadium(IV). PubMed: Glucose-lowering effects of a new organic vanadium complex, bis(maltolato)oxovanadium(IV). PubMed: Bis(maltolato)oxovanadium(IV) is a potent insulin mimic.