calcium citrate malate
2-hydroxy-1,2,3-propanetricarboxylic acid calcium salt, mixt. with hydroxybutanedioic acid calcium salt
Identification
| Name | calcium citrate malate |
| IUPAC | tetracalcium; 2-hydroxybutanedioate; 2-hydroxypropane-1,2,3-tricarboxylate |
| CAS Number | 142606-53-9 |
| FDA UNII | 4BBS3A53GJ |
| Molecular Formula | C16 H14 Ca4 O19 |
| Molecular Weight | 670.58438000 |
Regulatory
Physical Properties
| Assay | 98.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 309.00 to 310.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000057 mmHg @ 25.00 °C. (est) |
| Flash Point | 311.00 °F. TCC ( 155.20 °C. ) (est) |
| logP (o/w) | -1.721 (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | nutrient supplements |
| Recommendation for calcium citrate malate usage levels up to | not for fragrance use. |
| Recommendation for calcium citrate malate flavor usage levels up to | not for flavor use. |
American International Chemical, Inc.
Consistent sources
North American supplier for globally sourced ingredients.
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Potential Uses
Natural Occurrence
Synonyms
calcium 2-hydroxybutanedioate 2-hydroxypropane-1,2,3-tricarboxylate (4:1:2)
2-
hydroxy-1,2,3-propanetricarboxylic acid calcium salt, mixt. with hydroxybutanedioic acid calcium salt
1,2,3-
propanetricarboxylic acid, 2-hydroxy-, calcium salt, mixt. with hydroxybutanedioic acid calcium salt
tetracalcium; 2-hydroxybutanedioate; 2-hydroxypropane-1,2,3-tricarboxylate
PubMed:
An in-vitro assessment of erosive potential of a calcium-fortified fruit juice.
PubMed:
Assessment the levels of tartrate-resistant acid phosphatase (TRAP) on mice fed with eggshell calcium citrate malate.
PubMed:
Effect of intensive vs conventional insulin therapy on perioperative nutritional substrates metabolism in patients undergoing gastrectomy.
PubMed:
[Nutrition and bone health. Food for specified health use (FOSHU) and bone health].
PubMed:
The health benefits of calcium citrate malate: a review of the supporting science.
PubMed:
Calcium supplementation and bone mineral accretion in adolescent girls: an 18-mo randomized controlled trial with 2-y follow-up.
PubMed:
Calcium retention in adolescent boys on a range of controlled calcium intakes.
PubMed:
Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial.
PubMed:
I understand that older women should take 1,000-1,500 mg of calcium every day. I am 60, and my doctor recommends calcium citrate. However, a physical therapist I am seeing for a back problem says to take Os Cal. Which is best?
PubMed:
Calcium fortification systems differ in bioavailability.
PubMed:
Calcium and protein in bone health.
PubMed:
Interaction of dietary calcium and protein in bone health in humans.
PubMed:
Conserved residues R420 and Q428 in a cytoplasmic loop of the citrate/malate transporter CimH of Bacillus subtilis are accessible from the external face of the membrane.
PubMed:
Relative bioavailability of calcium-rich dietary sources in the elderly.
PubMed:
An investigation of calcium citrate-malate as a calcium source for young broiler chicks.
PubMed:
Selenium intakes, absorption, retention, and status in adolescent girls.
PubMed:
Absorption of calcium fumarate salts is equivalent to other calcium salts when measured in the rat model.
PubMed:
Calcium intake influences the association of protein intake with rates of bone loss in elderly men and women.
PubMed:
Fate of salmonellae in calcium-supplemented orange juice at refrigeration temperature.
PubMed:
Calcium and vitamin D supplements reduce tooth loss in the elderly.
PubMed:
Survival of salmonellae in pasteurized, refrigerated calcium-fortified orange juice.
PubMed:
Comparative absorption of calcium sources and calcium citrate malate for the prevention of osteoporosis.
PubMed:
Iron status, menarche, and calcium supplementation in adolescent girls.
PubMed:
Comparison of erosion of dental enamel by four drinks using an intra-oral applicance.
PubMed:
Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.
PubMed:
Calcium retention in relation to calcium intake and postmenarcheal age in adolescent females.
PubMed:
Zinc balance in adolescent females consuming a low- or high-calcium diet.
PubMed:
Effect of dietary calcium on urinary oxalate excretion after oxalate loads.
PubMed:
Calcium absorption from apple and orange juice fortified with calcium citrate malate (CCM).
PubMed:
Magnesium balance in adolescent females consuming a low- or high-calcium diet.
PubMed:
Lessening dental erosive potential by product modification.
PubMed:
The effect of calcium supplementation and Tanner stage on bone density, content and area in teenage women.
PubMed:
Inhibition of Western-diet induced hyperproliferation and hyperplasia in mouse colon by two sources of calcium.
PubMed:
Effect of calcium supplementation on blood pressure in children.
PubMed:
Supplementation trials with calcium citrate malate: evidence in favor of increasing the calcium RDA during childhood and adolescence.
PubMed:
Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals.
PubMed:
Effect of age, calcium source, and radiolabeling method on whole body 47Ca retention in the rat.
PubMed:
Calcium supplementation and bone mineral density in adolescent girls.
PubMed:
Short-term dietary calcium fortification increases fecal saturated fat content and reduces serum lipids in men.
PubMed:
Calcium supplementation and increases in bone mineral density in children.
PubMed:
Stone-forming potential of milk or calcium-fortified orange juice in idiopathic hypercalciuric adults.
PubMed:
Lactose, calcium source and age affect calcium bioavailability in rats.
PubMed:
Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women.
PubMed:
A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women.
PubMed:
Effect of calcium citrate-malate on skeletal development in young, growing rats.
PubMed:
Effects of different calcium sources on iron absorption in postmenopausal women.
PubMed:
Calcium absorption in children estimated from single and double stable calcium isotope techniques.
PubMed:
Calcium absorption from a new calcium delivery system (CCM).