(1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

CAS: 68489-09-8 C18 H27 N O2 MW: 289.41859000 minty cooling

Identification

NameWS-12
CAS Number68489-09-8
FDA UNII1L7BVT4Z4Z
Molecular FormulaC18 H27 N O2
Molecular Weight289.41859000
MDL NumberMFCD11100191
Nikkaji NumberJ2.926.766I

Regulatory

JECFA Food Flavoring2079 (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
DG SANTE Food Flavourings16.123 (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
FEMA Number4681
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)68489-09-8 ; (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE

Physical Properties

Appearance white crystals (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 177.70 °C. @ 760.00 mm Hg
Boiling Point 447.00 to 448.00 °C. @ 760.00 mm Hg (est)
Flash Point 436.00 °F. TCC ( 224.60 °C. ) (est)
logP (o/w) 5.017 (est)
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Odor Description at 100.00 %.
Taste Description cooling

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 [sex: F] > 2000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor enhancers, flavoring agents
Recommendation for WS-12 usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)12.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)150 (μg/person/day)
Threshold of Concern90 (μg/person/day)
Structure ClassIII
baked goods1.00000
beverages(nonalcoholic)1.00000
beverages(alcoholic)1.00000
breakfast cereal1.00000
cheese-
chewing gum100.00000
condiments / relishes-
confectionery froastings1.00000
egg products1.00000
fats / oils1.00000
fish products-
frozen dairy5.00000
fruit ices2.00000
gelatins / puddings2.00000
granulated sugar2.00000
gravies-
hard candy2.00000
imitation dairy1.00000
instant coffee / tea1.00000
jams / jellies2.00000
meat products-
milk products1.00000
nut products-
other grains-
poultry-
processed fruits1.00000
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy1.00000
soups1.00000
sugar substitutes1.00000
sweet sauces-
Dairy products, excluding products of category 02.0 (01.0)0.50000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)0.50000
Edible ices, including sherbet and sorbet (03.0)0.50000
Processed fruit (04.1)0.50000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)1.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)0.50000
Bakery wares (07.0)0.50000
Meat and meat products, including poultry and game (08.0)-
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)-
Eggs and egg products (10.0)0.50000
Sweeteners, including honey (11.0)1.00000
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)1.00000
Foodstuffs intended for particular nutritional uses (13.0)-
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)0.10000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)0.20000
Ready-to-eat savouries (15.0)-
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)-

BOC Sciences

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Chemical sources Association Inc

Exchange of knowledge

Need This Item for Flavor? You can contact the Chemical Sources Association.

M&U International LLC

Steady supply & demand

Meeting customers increasing demands at home as well as abroad.

View All Website 908-359-9000 sales@mu-intel.com

O'Laughlin Industries Inc.

Manufacturer of chemicals and ingredients used in flavors, fragrances, food, beverages and cosmetics

Leading the Flavor and Fragrance Industry since 1980.

View All Website (973) 376-4600 olcorphk@hkstar.com

Tianjin Danjun International Trade Co., LTD.

Quality Products

We know the Chinese chemical market well.

View All Website +86-15822601686 songshasha@danjunchem.com

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

cyclohexanecarboxamide, N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1R,2S,5R)- (1R,2S,5R)-N-(4- methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexane-carboxamide (1R,2S,5R)-N-(4- methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide (1R,2S,5R)-N-(4- methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide (1R,2S,5R)-2-iso propyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide PubMed: TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Leffingwell & Associates: Flavor Properties of FEMA GRAS List 25 flavor chemicals PubMed: Patient experiences at primary care practices using electronic health records. PubMed: Practicability and sensitivity to change of the activities-specific balance confidence scale and 12-item Walking Scale for stroke. PubMed: Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines. PubMed: Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons. PubMed: Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. PubMed: Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. PubMed: Characterisation of TRPM8 as a pharmacophore receptor. PubMed: Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators.