Identification

Nameresorcinol
IUPACbenzene-1,3-diol
CAS Number108-46-3
EINECS203-585-2
FDA UNIIYUL4LO94HK
Molecular FormulaC6 H6 O2
Molecular Weight110.11222000
MDL NumberMFCD00002269
Nikkaji NumberJ2.863K
Beilstein0906905
CoE Number11250
XlogP30.80 (est)

Regulatory

JECFA Food Flavoring712 resorcinol
DG SANTE Food Flavourings04.047 benzene-1,3-diol
DG SANTE Food Contact Materialsbenzene-1,3-diol
FEMA Number3589
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)108-46-3 ; RESORCINOL
FDA RegulationFDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS

Physical Properties

Appearance white to pale yellow brown solid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 110.00 to 112.00 °C. @ 760.00 mm Hg
Boiling Point 178.00 °C. @ 16.00 mm Hg, 281.00 to 281.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.002000 mmHg @ 25.00 °C. (est)
Vapor Density 3.8 ( Air = 1 )
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 0.800
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Description
at 1.00 % in propylene glycol.
creamy, vanilla
Odor sample from Harrmann & Reimer Corporation
Taste Description at 100.00 ppm.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 301 mg/kg
Dermal Toxicityskin-rabbit LD50 3360 mg/kg
Inhalation Toxicityinhalation-rat LCLo 160 mg/m3/1H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'CARDIAC: OTHER CHANGES\nBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD\nPERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE']

Safety in Use

Categoryfood contact closures with sealing gaskets for food containers
RIFM Fragrance Material Safety AssessmentSearch
Maximised Survey-derived Daily Intakes (MSDI-EU)1.20 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)0.30 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

FR cream FL cream sour cream hair dyeing agents FR vanilla

Natural Occurrence

jambul not found in nature

Synonyms

acnomel meta- benzene diol benzene-1,3-diol benzene, 1,3-dihydroxy- benzene, m-dihydroxy- 1,3- benzenediol m- benzenediol benzol-1,3-diol c.i. 76505 C.I. developer 4 C.I. oxidation base 31 ci 76505 developer O developer RS 1,3- dihydroxybenzene m- dihydroxybenzene meta- dihydroxybenzene dihydroxybenzol 1,3- dihydroxybenzol m- dioxybenzene meta- dioxybenzene durafur developer G eskamel fouramine RS fourrine 79 fourrine EW hexylresorcinol Imp. B (EP) m- hydroquinone meta- hydroquinone 3- hydroxycyclohexadien-1-one 3- hydroxyphenol m- hydroxyphenol meta- hydroxyphenol hymecromone Imp. A (EP) nako TGG pelagol RS phenol, m-hydroxy- phoroglucin RESO resorcin resorcine a- resorcinol resorcinol (c.i. 76505) resorcinol food grade resorcinol USP resorcinol, tech. resorzin PubMed: Inhibitory effects of cardols and related compounds on superoxide anion generation by xanthine oxidase. PubMed: A novel 4-(2-pyridylazo) resorcinol functionalised magnetic nanosorbent for selective extraction of Cu(II) and Pb(II) ions from food and water samples. PubMed: 2-Alkenal-scavenging ability of m-diphenols. PubMed: Essential Structural Requirements and Additive Effects for Flavonoids to Scavenge Methylglyoxal. PubMed: Determination of synthetic by-products and an intermediate in the colour additives D&C Red Nos 27 and 28 (phloxine B) and their lakes using conventional HPLC. PubMed: Structural characteristics that determine the inhibitory role of phenolic compounds on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation. PubMed: Development and validation of a micromethod for fast quantification of 5-n-alkylresorcinols in grains and whole grain products. PubMed: Analysis of alkylresorcinols in cereal grains and products using ultrahigh-pressure liquid chromatography with fluorescence, ultraviolet, and CoulArray electrochemical detection. PubMed: Determination of synthetic by-products and an intermediate in the colour additive D&C Orange No. 5 using high-performance liquid chromatography. PubMed: Metabolism of oak leaf ellagitannins and urolithin production in beef cattle. PubMed: Antibacterial activity of the plant-derived compounds 23-methyl-6-O-desmethylauricepyrone and (Z,Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus. PubMed: In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations. PubMed: Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity. PubMed: ESI-MS quantitation of iron as its 4-(2-pyridylazo)resorcinol (PAR) complex: application to pharmaceutical tablets containing iron oxide pigment. PubMed: Effect of pasteurization on selected immune components of donated human breast milk. PubMed: Irreversible competitive inhibitory kinetics of cardol triene on mushroom tyrosinase. PubMed: Essential oils, phenolics, and antioxidant activities of different parts of cumin (Cuminum cyminum L.). PubMed: Resveratrol and its oligomers from wine grapes are selective (1)O2 quenchers: mechanistic implication by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry and theoretical calculation. PubMed: Classification of benzoyl peroxide as safe and effective and revision of labeling to drug facts format; topical acne drug products for over-the-counter human use; final rule. PubMed: Improving the stability and antioxidant properties of sesame oil: water-soluble spray-dried emulsions from new transesterified phenolic derivatives. PubMed: Bioremediation of a polyaromatic hydrocarbon contaminated soil by native soil microbiota and bioaugmentation with isolated microbial consortia. PubMed: Alkaline phosphatase-polyresorcinol complex: characterization and application to seed coating. PubMed: Tyrosinase inhibitory polyphenols from roots of Morus lhou. PubMed: Alkylresorcinols in wheat varieties in the HEALTHGRAIN Diversity Screen. PubMed: Analysis of cyanogens with resorcinol and picrate. PubMed: Quantification of alkylresorcinol metabolites in plasma by high-performance liquid chromatography with coulometric electrode array detection. PubMed: A preconcentration system for determination of copper and nickel in water and food samples employing flame atomic absorption spectrometry. PubMed: Total antioxidant capacity and content of flavonoids and other phenolic compounds in canihua (Chenopodium pallidicaule): an Andean pseudocereal. PubMed: Stopped-flow kinetic study of the aroxyl radical-scavenging action of catechins and vitamin C in ethanol and micellar solutions. PubMed: Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor. PubMed: Anti-inflammatory 5-(11'Z-heptadecenyl)- and 5-(8'Z,11'Z-heptadecadienyl)-resorcinols from mango (Mangifera indica L.) peels. PubMed: 2-Aminoresorcinol is a potent alpha-glucosidase inhibitor. PubMed: Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. PubMed: Polyphenol oxidase from yacon roots (Smallanthus sonchifolius). PubMed: Stacked films immobilization of MBTH in nafion/sol-gel silicate and horseradish peroxidase in chitosan for the determination of phenolic compounds. PubMed: Determination of 2,4,6-triiodoresorcinol and other side reaction products and intermediates in the colour additive FD&C Red No. 3 (erythrosine) using high-performance liquid chromatography. PubMed: Colorimetric evaluation of phenolic content and GC-MS characterization of phenolic composition of alimentary and cosmetic argan oil and press cake. PubMed: Simultaneous determination of cobalt, copper and zinc by energy dispersive X-ray fluorescence spectrometry after preconcentration on PAR-loaded ion-exchange resin. PubMed: Evaluation of dry ashing in conjunction with ion chromatographic determination of transition metal ions in pig feed samples. PubMed: Chromatographic analysis of alkylresorcinols and their metabolites. PubMed: Identification of cereal alkylresorcinol metabolites in human urine-potential biomarkers of wholegrain wheat and rye intake. PubMed: Estimation of scavenging activity of phenolic compounds using the ABTS(*+) assay. PubMed: Sterol ferulates, sterols, and 5-alk(en)ylresorcinols from wheat, rye, and corn bran oils and their inhibitory effects on Epstein-Barr virus activation. PubMed: Method for analysis of tannic acid and its metabolites in biological samples: application to tannic acid metabolism in the rat. PubMed: Free radical chemistry of flavan-3-ols: determination of thermodynamic parameters and of kinetic reactivity from short (ns) to long (ms) time scale. PubMed: Simultaneous and sensitive analysis of Cu, Ni, Zn, Co, Mn, and Fe in food and biological samples by ion chromatography. PubMed: Evaluation of the potential effects of ingredients added to cigarettes. Part 2: chemical composition of mainstream smoke. PubMed: Oxidation of polyphenols in phytate-reduced high-tannin cereals: effect on different phenolic groups and on in vitro accessible iron. PubMed: GC-MS analysis of hydrophobic root exudates of sorghum and implications on the parasitic plant Striga asiatica. PubMed: Transglycosylation by Streptococcus mutans GS-5 glucosyltransferase-D: acceptor specificity and engineering of reaction conditions. PubMed: Structure-activity relationship of polyphenols on inhibition of chemical mediator release from rat peritoneal exudate cells. PubMed: Pigment producing yeasts involved in the brown surface discoloration of ewes' cheese. PubMed: Systemic contact dermatitis to raw cashew nuts in a pesto sauce. PubMed: Potential for an external vaginal antiitch cream containing benzocaine to cause methemoglobinemia in healthy women. PubMed: Effect of tea polyphenols on histamine release from rat basophilic leukemia (RBL-2H3) cells: the structure-inhibitory activity relationship. PubMed: Transcriptional regulation of the human NAD(P)H:quinone oxidoreductase (NQO1) gene by monofunctional inducers. PubMed: Sensitization of mice to paraphenylenediamine and structurally-related compounds: adjuvant effects of vitamin A supplementation. PubMed: Mechanism-based inactivation of lactoperoxidase and thyroid peroxidase by resorcinol derivatives. PubMed: Radiochemical neutron activation analysis of Fe, Co, Zn, Sb and Se in biomedical and environmental samples. PubMed: Forestomach neoplasms in Fischer F344/N rats and B6C3F1 mice exposed to diglycidyl resorcinol ether--an epoxy resin. PubMed: Multigeneration reproduction and carcinogenicity studies in Sprague-Dawley rats exposed topically to oxidative hair-colouring formulations containing p-phenylenediamine and other aromatic amines. PubMed: Detection of GD3 ganglioside in childhood acute lymphoblastic leukemia with monoclonal antibody to GD3: restriction to immunophenotypically defined T-cell disease. PubMed: Increased antimutagenic activity of simple substituted phenols mixed with the hindered phenolic antioxidant dibunol. PubMed: Eugenol-mediated superoxide generation and cytotoxicity in guinea pig neutrophils. PubMed: [Application of the Ti(IV)-4-(2-pyridylazo)resorcinol reagent to the determination of hydrogen peroxide and sulfite as food additives]. PubMed: Mutagenicity of commercial hair dyes in Salmonella typhimurium TA98. PubMed: Mutagenicity of commercial p-phenylenediamine and of an oxidation mixture of p-phenylenediamine and resorcinol in Salmonella typhimurium TA98. PubMed: [Analytical methods for nitrate and nitrite determination in foods. 3. Spectrophotometric determination of nitrate and nitrite using sulphanilic acid/1-naphylamine, and of nitrite using resorcinol/zirconium (IV) oxychloride]. PubMed: Effect of Phloroglucinol and Resorcinol on the Clingstone Peach Polyphenol Oxidase-catalyzed Oxidation of 4-Methylcatechol. PubMed: [4-(Pyridylazo)-resorcinol as an analytical reagent for the colorimetric determination of lead in food].