3-butyn-1-ol

2-hydroxyethylacetylene

CAS: 927-74-2 C4 H6 O MW: 70.09102000

Identification

Name3-butyn-1-ol
IUPACbut-3-yn-1-ol
CAS Number927-74-2
EINECS213-161-9
FDA UNIIP74L430293
Molecular FormulaC4 H6 O
Molecular Weight70.09102000
MDL NumberMFCD00002955
Nikkaji NumberJ1.744B
Beilstein0773710

Regulatory

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point -63.60 °C. @ 760.00 mm Hg
Boiling Point 129.00 °C. @ 760.00 mm Hg
Vapor Pressure 4.411000 mmHg @ 25.00 °C. (est)
Flash Point 97.00 °F. TCC ( 36.10 °C. ) (est)
logP (o/w) 0.130 (est)
Soluble in alcohol
Insoluble in water

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-mouse LD50 100 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#05171']

Safety in Use

Categorynatural substances and extractives
Recommendation for 3-butyn-1-ol usage levels up tonot for fragrance use.
Recommendation for 3-butyn-1-ol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

but-3-yn-1-ol 2- hydroxyethylacetylene PubMed: Reactivity of Cl atom with triple-bonded molecules. An experimental and theoretical study with alcohols. PubMed: The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor. PubMed: Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction. PubMed: A novel approach toward asymmetric synthesis of alcohol functionalized C-chiral diphosphines via two-stage hydrophosphination of terminal alkynols. PubMed: Calorimetric and computational study of 3-buten-1-ol and 3-butyn-1-ol. Estimation of the enthalpies of formation of 1-alkenols and 1-alkynols. PubMed: Synthesis, characterisation and molecular structure of Re(III) 2-oxacyclocarbenes stabilised by a benzoyldiazenido ligand. PubMed: 3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors. PubMed: Total synthesis of (+/-)-kainic Acid with an aza-[2,3]-Wittig sigmatropic rearrangement as the key stereochemical determining step. PubMed: RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. PubMed: Lipase specificity toward some acetylenic and olefinic alcohols in the esterification of pentanoic and stearic acids. PubMed: Ion-molecule reactions and collision-activated dissociation of C4H 4 (+.) isomers: A case study in the use of the MS (3) capabilities of a pentaquadrupole mass spectrometer. PubMed: Replacement of carcinogenic alkylating agent ethylene oxide in the synthesis of (Z)-3-dodecen-1-YL (E)-2-butenoate, sex pheromone of sweet-potato weevil,Cylas formicarius elegantulus (summers) andCylas formicarius formicarius (F.). PubMed: The toxicity of acetylenic alcohols to the fathead minnow, Pimephales promelas: narcosis and proelectrophile activation. PubMed: Stereospecific synthesis of (Z,Z)-3,5-tetradecadienoic acid, a component ofAttagenus elongatulus (Casey) pheromone. PubMed: Inactivation of alcohol dehydrogenase by 3-butyn-1-ol.