peg/ppg-98/67 copolymer

oxirane, methyl, polymer with oxirane (98 mol EO, 67 mol PO average molar ratio)

CAS: 9003-11-6 (C3 H6 O.C2 H4 O)x-

Identification

Namepeg/ppg-98/67 copolymer
IUPAC2-methyloxirane; oxirane (98;67)
CAS Number9003-11-6
FDA UNIISearch
Molecular Formula(C3 H6 O.C2 H4 O)x-

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesFCN 1020
FDA Mainterm (SATF)9003-11-6 ; ETHYLENE OXIDE/PROPYLENE OXIDE COPOLYMER
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 275.31 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Flash Point 249.00 °F. TCC ( 120.30 °C. ) (est)
logP (o/w) -1.293 (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usessurfactants

No sensory data available

Safety Information

Oral/Parenteral Toxicityintravenous-mouse LD50 175 mg/kg
Dermal ToxicityNot determined
Inhalation Toxicityinhalation-rat LC50 320 mg/m3/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryemulsifiers and foaming agents
Recommendation for peg/ppg-98/67 copolymer usage levels up tonot for fragrance use.
Recommendation for peg/ppg-98/67 copolymer flavor usage levels up tonot for flavor use.

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Potential Uses

emollients emulsifying agents humectants solvents surfactants

Natural Occurrence

not found in nature

Synonyms

methyl oxirane polymer with oxirane (98;67) 2- methyloxirane; oxirane (98;67) oxirane, methyl, polymer with oxirane (98 mol EO, 67 mol PO average molar ratio) pluracare F 127 pluronic P-123 poloxamer 407 PubMed: Effect of interfacial composition on uptake of curcumin-piperine mixtures in oil in water emulsions by Caco-2 cells. PubMed: Simvastatin treatment upregulates intestinal lipid secretion pathways in a rodent model of the metabolic syndrome. PubMed: Mechanical, rheological and release behaviors of a poloxamer 407/ poloxamer 188/carbopol 940 thermosensitive composite hydrogel. PubMed: Antidiabetic activity and molecular docking of fructooligosaccharides produced by Aureobasidium pullulans in poloxamer-407-induced T2DM rats. PubMed: Potent dried drug nanosuspensions for oral bioavailability enhancement of poorly soluble drugs with pH-dependent solubility. PubMed: Regulatory function of a malleable protein matrix as a novel fermented whey product on features defining the metabolic syndrome. PubMed: Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. PubMed: Pharmacokinetics of Amiodarone in hyperlipidemic and simulated high fat-meal rat models. PubMed: The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins. PubMed: Poloxamer 407-mediated changes in plasma cholesterol and triglycerides following intraperitoneal injection to rats.