1-methyl-2-pyrrolidinone

2-pyrrolidone, 1-methyl

C5 H9 N O MW: 99.13293000

Identification

Name1-methyl-2-pyrrolidinone
IUPAC1-methylpyrrolidin-2-one
EINECS212-828-1
FDA UNIISearch
Molecular FormulaC5 H9 N O
Molecular Weight99.13293000
MDL NumberMFCD00003193
Nikkaji NumberJ26.033I
Beilstein106420
XlogP3-0.50 (est)

Regulatory

FDA Mainterm (IAUFC)872-50-4 ; N-METHYL-2-PYRROLIDONE

Physical Properties

Appearance colorless clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point -25.00 °C. @ 760.00 mm Hg (est)
Boiling Point 202.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.345000 mmHg @ 25.00 °C. (est)
Vapor Density 3.4 ( Air = 1 )
Flash Point 187.00 °F. TCC ( 86.10 °C. ) (est)
logP (o/w) -0.380
Soluble in water, 1.00E+06 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usessolvents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-dog LD50 63300 ug/kg
Dermal Toxicityskin-rabbit LD50 8000 mg/kg
Inhalation Toxicityinhalation-rat LCLo 1000 mg/m3

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysolvents
Recommendation for 1-methyl-2-pyrrolidinone usage levels up tonot for fragrance use.
Recommendation for 1-methyl-2-pyrrolidinone flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

View All Website +41 91 695 88 00 marketing@ecsa.ch

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

M-pyrol N- methyl pyrrolidone N- methyl-2-ketopyrrolidine N- methyl-2-pyrolidinone N- methyl-2-pyrrolidinone 1- methyl-2-pyrrolidone N- methyl-2-pyrrolidone N- methyl-a-pyrrolidinone N- methyl-a-pyrrolidone 1- methyl-pyrrolidin-2-one N- methyl-pyrrolidone N- methylbutyrolactam 1- methylpyrrolidin-2-one N- methylpyrrolidin-2-one methylpyrrolidinone N- methylpyrrolidinone N- methylpyrrolidione N- methylpyrrolidone methylpyrrolidone, N- pyrrolidin-2-one, 1-methyl- 2- pyrrolidinone, 1-methyl- pyrrolidinone, methyl- 2- pyrrolidinone, methyl- 2- pyrrolidone, 1-methyl PubMed: Homogeneous ring opening graft polymerization of ɛ-caprolactone onto xylan in dual polar aprotic solvents. PubMed: Star-shaped poly(L-lactide)-b-poly(lactobionamidoethyl methacrylate) with porphyrin core: synthesis, self-assembly, singlet oxygen research and recognition properties. PubMed: Direct synthesis of α-trifluoromethyl ketone from (hetero)arylacetylene: design, intermediate trapping, and mechanistic investigations. PubMed: Effective liquid-phase exfoliation and sodium ion battery application of MoS2 nanosheets. PubMed: Liquid-phase exfoliation of graphene in organic solvents with addition of naphthalene. PubMed: Ultrahigh PEMFC performance of a thin-film, dual-electrode assembly with tailored electrode morphology. PubMed: Carbon nanotube poroshell silica as a novel stationary phase for fast HPLC analysis of monoclonal antibodies. PubMed: Development and pharmacokinetic evaluation of a curcumin co-solvent formulation. PubMed: Fouling mitigation in humic acid ultrafiltration using polysulfone/SAPO-34 mixed matrix membrane. PubMed: Chemical and biological characterization of wastewater generated from hydrothermal liquefaction of Spirulina. PubMed: Noninvasive characterization of the effect of varying PLGA molecular weight blends on in situ forming implant behavior using ultrasound imaging. PubMed: Non-covalent functionalisation of monolithic silica for the development of carbon nanotube HPLC stationary phases. PubMed: Porosity and mechanically optimized PLGA based in situ hardening systems. PubMed: Effects of pentacene-doped PEDOT:PSS as a hole-conducting layer on the performance characteristics of polymer photovoltaic cells. PubMed: Partial dissolution of ACQ-treated wood in lithium chloride/N-methyl-2-pyrrolidinone: separation of copper from potential lignocellulosic feedstocks. PubMed: Delivery of atovaquone and proguanil across sublingual membranes, in vitro. PubMed: Rare earth fluoride nanoparticles obtained using charge transfer complexes: a versatile and efficient route toward colloidal suspensions and monolithic transparent xerogels. PubMed: Effects of electrochemical reduction reactions on the biodegradation of recalcitrant organic compounds (ROCs) and bacterial community diversity. PubMed: Facile synthesis of MOF-177 by a sonochemical method using 1-methyl-2-pyrrolidinone as a solvent. PubMed: Characterization of formulation parameters affecting low molecular weight drug release from in situ forming drug delivery systems. PubMed: Noninvasive characterization of in situ forming implants using diagnostic ultrasound. PubMed: SAXS and NMR analysis for the cast solvent effect on sPEEK membrane properties. PubMed: Pyrolysis of waste polypropylene and characterisation of tar. PubMed: The use of oxygen uptake rate to monitor discovery of microbial and enzymatic biocatalysts. PubMed: Human bone derived cell culture on PLGA flat sheet membranes of different lactide:glycolide ratio. PubMed: Kinetics of amide formation through carbodiimide/N-hydroxybenzotriazole (HOBt) couplings. PubMed: [Discharge ion mobility spectrometry of ketonic organic compounds]. PubMed: Control of EOF in CE by different ways of application of radial electric field. PubMed: Phase separation micromolding: a new generic approach for microstructuring various materials. PubMed: Poly(lactic-co-glycolic acid) hollow fibre membranes for use as a tissue engineering scaffold. PubMed: Unexpected reaction of beta-cyclodextrin tosylate with pyrrolidinones. PubMed: Examination of soil contaminated by coal-liquids by size exclusion chromatography in 1-methyl-2-pyrrolidinone solution to evaluate interference from humic and fulvic acids and extracts from peat. PubMed: [Effect of tegaserod on the serotonin content in rat ileocaecal mucosa under partial restraint stress]. PubMed: Affinity enhancement bivalent morpholino for pretargeting: initial evidence by surface plasmon resonance. PubMed: Relevance of Frank's solvent classification as typically aqueous and typically non-aqueous to activities of firefly luciferase, alcohol dehydrogenase, and alpha-chymotrypsin in aqueous binaries. PubMed: Wetting kinetics of modified polyimide surfaces: interactions with polar solvents. PubMed: Estimation of the molecular mass range of the tar from pyrolysis of casein by gas chromatography-mass spectrometry, probe mass spectrometry and size exclusion chromatography with 1-methyl-2-pyrrolidinone as eluent. PubMed: Use of an 8(1)3(2) asymmetrical factorial design for the in vitro evaluation of ondansetron permeation through human epidermis. PubMed: Thin-layer chromatography of pitch and a petroleum vacuum residue. Relation between mobility and molecular size shown by size-exclusion chromatography. PubMed: Size-exclusion chromatography of large molecules from coal liquids, petroleum residues, soots, biomass tars and humic substances. PubMed: Through-shell alkyllithium additions and borane reductions. PubMed: The effect of Pluronic on the protein release kinetics of an injectable drug delivery system. PubMed: Toxicokinetics and metabolism of N-[14C]methylpyrrolidone in male Sprague-Dawley rats. A saturable NMP elimination process. PubMed: Dermal exposure to aqueous solutions of N-methyl pyrrolidone. PubMed: Pyrolysis-gas chromatography/mass spectrometry of fractions separated from a low-temperature coal tar: an attempt to develop a general method for characterising structures and compositions of heavy hydrocarbon liquids. PubMed: A new, efficient glycosylation method for oligosaccharide synthesis under neutral conditions: preparation and use of new DISAL donors. PubMed: Study of the polymerization of anthracene oil with AlCl3 by chromatography and related techniques. PubMed: Liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry determination of N-methylpyrrolidinone in riverine biofilms. PubMed: Structural characterisation of Baltic amber and its solvent extracts by several mass spectrometric methods. PubMed: Syntheses and characterization of anti-inflammatory dinuclear and mononuclear zinc indomethacin complexes. Crystal structures of [Zn2(indomethacin)4(L)2] (L = N,N-dimethylacetamide, pyridine, 1-methyl-2-pyrrolidinone) and [Zn(indomethacin)2(L1)2] (L1 = ethanol, methanol). PubMed: HPTLC screening assay for urinary cotinine as biomarker of environmental tobacco smoke exposure among male adolescents. PubMed: Identification of organically associated trace elements in wood and coal by inductively coupled plasma mass spectrometry. PubMed: Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bath-side mass transfer. PubMed: Photodynamic activities and biodistribution of fluorinated zinc phthalocyanine derivatives in the murine EMT-6 tumour model. PubMed: Synthesis, Structure, and Thiolysis Reactions of Pyridine Soluble Alkaline Earth and Yttrium Thiolates. PubMed: Determination of 5-hydroxy-N-methylpyrrolidone and 2-hydroxy-N-methylsuccinimide in human urine. PubMed: 1-Methyl-2-pyrrolidinone (NMP) does not induce structural and numerical chromosomal aberrations in vivo. PubMed: Characterization of polymorphs and solvates of 3-amino-1-(m-trifluoromethylphenyl)-6-methyl-1H-pyridazin-4-one. PubMed: Synthesis of insulin-like growth factor I using N-methyl pyrrolidinone as the coupling solvent and trifluoromethane sulphonic acid cleavage from the resin. PubMed: Transdermal absorption of radioprotectors using permeation-enhancing vehicles. PubMed: Induction of chromosome loss by mixtures of organic solvents including neurotoxins. PubMed: Aprotic polar solvents that affect porcine brain tubulin aggregation in vitro induce aneuploidy in yeast cells growing at low temperatures. PubMed: Investigations of aneuploidy-inducing chemical combinations in Saccharomyces cerevisiae. PubMed: Aneuploidy induction in Saccharomyces cerevisiae by two solvent compounds, 1-methyl-2-pyrrolidinone and 2-pyrrolidinone. PubMed: Nonheritable resistance to chloramphenicol and other antibiotics induced by salicylates and other chemotactic repellents in Escherichia coli K-12. PubMed: Degradation of chlorthalidone in methanol: kinetics and stabilization.