broxuridine
5-bromo-2'-deoxyuridine
Identification
| Name | broxuridine |
| IUPAC | 5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| CAS Number | 59-14-3 |
| EINECS | 200-415-9 |
| FDA UNII | G34N38R2N1 |
| Molecular Formula | C9 H11 Br N2 O5 |
| Molecular Weight | 307.10067000 |
| MDL Number | MFCD00006529 |
| Nikkaji Number | J2.335C |
| Beilstein | 0030395 |
| XlogP3 | -0.30 (est) |
Regulatory
Physical Properties
| Appearance | white crystalline powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 192.50 °C. @ 760.00 mm Hg |
| Vapor Pressure | 1.700000 mmHg @ 25.00 °C. (est) |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | -0.290 |
| Soluble in | water, 966.6 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 3050 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 3500 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for broxuridine usage levels up to | not for fragrance use. |
| Recommendation for broxuridine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
brdurd
5-
bromo-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
5-
bromo-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
5-
bromo-1-(2-deoxy-b-D-ribofuranosyl)uracil
5-
bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
(+)-5-
bromo-2-deoxyuridine
(+)-5-
bromo-2'-deoxyuridine
5-
bromo-2'-deoxyuridine
bromodeoxyuridine
5-
bromodeoxyuridine
5-
bromodesoxyuridine
bromoouridine
bromouracil deoxyriboside
5-
bromouracil deoxyriboside
5-
bromouracil-2-deoxyriboside
1-[(4S,2R,5R)-4-
hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-bromo-1,3-dihydropyrimidine-2,4-dione
radibud
uridine, 5-bromo-2'-deoxy-
PubMed:
[A combined therapy for maxillary cancer].
PubMed:
Effects of orally administered 5-fluorouracil and its derivative 5'-deoxy-5-fluorouridine on 7,12-dimethylbenz[a]anthracene-induced breast carcinomas in rats.
PubMed:
[A combined treatment of carcinoma of the maxillary sinus--treatment method for T4 cases].
PubMed:
Distinctive eruption characterized by linear supravenous papules and erythroderma following broxuridine (bromodeoxyuridine) therapy and radiotherapy.
PubMed:
[Treatment of maxillary cancer].
PubMed:
[Effects of oxygen and broxuridine on the cytotoxic effects of D-T neutrons and x-rays].
PubMed:
Combined surgery, radiotherapy and regional chemotherapy in carcinoma of the maxillary sinus.